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Literature DB >> 3884494

The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies.

R A de Maagd, W A MacKenzie, H J Schuurman, M A Ritter, K M Price, R Broekhuizen, L Kater.

Abstract

Monoclonal antibodies were raised against human thymus stromal cells and their specificity for the epithelial component of thymus stroma assessed by double immunofluorescence using anti-keratin antibodies to identify epithelium. Our monoclonal antibodies identify six distinct patterns of epithelial cell antigen expression within the thymus: pan epithelial (antibody IP1); cortex (MR3 and MR6); cortical/medullary junction (IP2); subcapsule and subpopulation of medulla (MR10/MR14); Hassall's corpuscles and adjacent subpopulation of medulla (IP3); Hassall's corpuscles only (MR13/IP4). This heterogeneity of antigen expression suggests that many different epithelial microenvironments exist within the human thymus.

Entities: Chemical Disease Gene Species

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Year: 1985 PMID： 3884494 PMCID： PMC1453544

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

13 in total

1. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors: J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

2. Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors: G Köhler; C Milstein
Journal: Nature Date: 1975-08-07 Impact factor: 49.962

3. The dynamic behaviour of Hassall's corpuscles and the transport of particulate matter in the thymus of the guinea-pig.

Authors: J N Blau
Journal: Immunology Date: 1967-09 Impact factor: 7.397

4. The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.

Authors: E J McFarland; R M Scearce; B F Haynes
Journal: J Immunol Date: 1984-09 Impact factor: 5.422

5. Heterogeneity of epithelial cells in the human thymus. An ultrastructural study.

Authors: F P van de Wijngaert; M D Kendall; H J Schuurman; L H Rademakers; L Kater
Journal: Cell Tissue Res Date: 1984 Impact factor: 5.249

6. Presence of thymosin-like factors in human thymic epithelium conditioned medium.

Authors: L Kater; R Oosterom; J McClure; A L Goldstein
Journal: Int J Immunopharmacol Date: 1979

7. Identification and in situ localization of the "thymic nurse cell" in man.

Authors: F P van de Wijngaert; L H Rademakers; H J Schuurman; R A de Weger; L Kater
Journal: J Immunol Date: 1983-05 Impact factor: 5.422

8. Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.

Authors: B F Haynes; K Shimizu; G S Eisenbarth
Journal: J Clin Invest Date: 1983-01 Impact factor: 14.808

9. Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies.

Authors: W Savino; M Dardenne; M Papiernik; J F Bach
Journal: J Exp Med Date: 1982-08-01 Impact factor: 14.307

10. Location of T cell and major histocompatibility complex antigens in the human thymus.

Authors: A K Bhan; E L Reinherz; S Poppema; R T McCluskey; S F Schlossman
Journal: J Exp Med Date: 1980-10-01 Impact factor: 14.307

39 in total

Review 1. Functional histology of the human thymus.

Authors: B von Gaudecker
Journal: Anat Embryol (Berl) Date: 1991

2. Cultured human thymus epithelial monolayer cells induce CD4 expression on mononuclear cells of AIDS patients in vitro.

Authors: H J Schuurman; R W Hendriks; J M Lange; J A van der Linden; F H Gmelig Meyling; S A Danner; L Kater
Journal: Clin Exp Immunol Date: 1986-05 Impact factor: 4.330

Review 3. Functional anatomy of the thymic microenvironment.

Authors: M D Kendall
Journal: J Anat Date: 1991-08 Impact factor: 2.610

4. A new monoclonal antibody to human subcapsular thymic epithelial cells.

Authors: T Takeuchi; I Kubonishi; Y Ohtsuki; I Miyoshi
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1991

5. Immunohistochemical characterization of the thymic microenvironment. A light-microscopic and ultrastructural immunocytochemical study.

Authors: B von Gaudecker; G G Steinmann; M L Hansmann; J Harpprecht; N M Milicevic; H K Müller-Hermelink
Journal: Cell Tissue Res Date: 1986 Impact factor: 5.249

6. The bursal microenvironment: phenotypic characterization of the epithelial component of the bursa of Fabricius with the use of monoclonal antibodies.

Authors: E Houssaint; E Diez; M M Hallet
Journal: Immunology Date: 1986-05 Impact factor: 7.397