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Literature DB >> 3877934

Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.

Abstract

An enzymatic dispersion procedure has been developed to obtain viable, spontaneously active single myocytes from cardiac pacemaker tissue: the bullfrog (Rana catesbeiana) sinus venosus. Recordings of time- and voltage-dependent Ca2+ and K+ currents have been made by using a single suction-microelectrode technique. The results show that two time- and voltage-dependent currents interact to modulate the slope of the pacemaker potential. These are: (i) the decay of a delayed rectifier K+ current and (ii) the activation of a Ca2+ current. In addition, the data strongly suggest that cardiac pacemaker tissue does not have an inwardly rectifying background K+ current.

Entities: Chemical Species

Mesh：

Substances：
Potassium
Calcium

Year: 1985 PMID： 3877934 PMCID： PMC391421 DOI： 10.1073/pnas.82.22.7796

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

9. Voltage clamp measurements of the hyperpolarization-activated inward current I(f) in single cells from rabbit sino-atrial node.

Authors: A C van Ginneken; W Giles
Journal: J Physiol Date: 1991-03 Impact factor: 5.182

10. A model of the muscarinic receptor-induced changes in K(+)-current and action potentials in the bullfrog atrial cell.

Authors: J M Shumaker; J W Clark; W R Giles; G Szabo
Journal: Biophys J Date: 1990-03 Impact factor: 4.033

Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.

1. A Fourier method for the analysis of exponential decay curves.

2. Membrane currents underlying activity in frog sinus venosus.

Review 3. Comparative physiology of the cardiac pacemaker mechanism.

4. Resting K conductances in pacemaker and non-pacemaker heart cells of the rabbit.

5. Autonomic transmitter actions on cardiac pacemaker tissue: a brief review.

6. Inward current activated during hyperpolarization in the rabbit sinoatrial node cell.

7. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

8. Functional and morphological organization of the rabbit sinus node.

9. Structures of physiological interest in the frog heart ventricle.

10. Active and passive electrical properties of single bullfrog atrial cells.

1. Electrophysiology of single heart cells from the rabbit tricuspid valve.

2. Isolated cells of the frog sinus venosus: properties of the inward current activated during hyperpolarization.

3. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes.

Review 4. Modern concepts concerning the origin of the heartbeat.

Review 5. Current concepts of anatomy and electrophysiology of the sinus node.

6. Comparison of potassium currents in rabbit atrial and ventricular cells.

7. Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes.

8. Two distinct types of inwardly rectifying K+ channels in bull-frog atrial myocytes.

9. Voltage clamp measurements of the hyperpolarization-activated inward current I(f) in single cells from rabbit sino-atrial node.

10. A model of the muscarinic receptor-induced changes in K(+)-current and action potentials in the bullfrog atrial cell.