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Literature DB >> 23455768

Modern concepts concerning the origin of the heartbeat.

Oliver Monfredi¹, Victor A Maltsev, Edward G Lakatta.

Abstract

Physiological processes governing the heart beat have been under investigation for several hundred years. Major advances have been made in the recent past. A review of the present paradigm is presented here, including a look back at important steps that led us to where we are today, alongside a glimpse into the exciting future of pacemaker research.

Mesh：

Year: 2013 PMID： 23455768 PMCID： PMC3768086 DOI： 10.1152/physiol.00054.2012

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

76 in total

1. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.

Authors: Stefan Herrmann; Juliane Stieber; Georg Stöckl; Franz Hofmann; Andreas Ludwig
Journal: EMBO J Date: 2007-10-04 Impact factor: 11.598

Review 2. Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells.

Authors: Victor A Maltsev; Edward G Lakatta
Journal: Heart Lung Circ Date: 2007-09-10 Impact factor: 2.975

Review 3. Genesis and regulation of the heart automaticity.

Authors: Matteo E Mangoni; Joël Nargeot
Journal: Physiol Rev Date: 2008-07 Impact factor: 37.312

4. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.

Authors: Carlo Cifelli; Robert A Rose; Hangjun Zhang; Julia Voigtlaender-Bolz; Steffen-Sebastian Bolz; Peter H Backx; Scott P Heximer
Journal: Circ Res Date: 2008-07-24 Impact factor: 17.367

5. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.

Authors: Natalie J Chandler; Ian D Greener; James O Tellez; Shin Inada; Hanny Musa; Peter Molenaar; Dario Difrancesco; Mirko Baruscotti; Renato Longhi; Robert H Anderson; Rudolf Billeter; Vinod Sharma; Daniel C Sigg; Mark R Boyett; Halina Dobrzynski
Journal: Circulation Date: 2009-03-16 Impact factor: 29.690

6. Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.

Authors: Tatiana M Vinogradova; Syevda Sirenko; Alexey E Lyashkov; Antoine Younes; Yue Li; Weizhong Zhu; Dongmei Yang; Abdul M Ruknudin; Harold Spurgeon; Edward G Lakatta
Journal: Circ Res Date: 2008-02-14 Impact factor: 17.367

Review 7. Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function.

Authors: Victor A Maltsev; Edward G Lakatta
Journal: Cardiovasc Res Date: 2007-11-05 Impact factor: 10.787

8. Tamoxifen-inducible gene deletion in the cardiac conduction system.

Authors: Evelyn Hoesl; Juliane Stieber; Stefan Herrmann; Susanne Feil; Elisabeth Tybl; Franz Hofmann; Robert Feil; Andreas Ludwig
Journal: J Mol Cell Cardiol Date: 2008-04-30 Impact factor: 5.000

9. Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

Authors: Dagmar Harzheim; K Holger Pfeiffer; Larissa Fabritz; Elisabeth Kremmer; Thorsten Buch; Ari Waisman; Paulus Kirchhof; U Benjamin Kaupp; Reinhard Seifert
Journal: EMBO J Date: 2008-01-24 Impact factor: 11.598

10. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.

Authors: Victor A Maltsev; Edward G Lakatta
Journal: Am J Physiol Heart Circ Physiol Date: 2009-01-09 Impact factor: 4.733

37 in total

1. Biology of the Sinus Node and its Disease.

Authors: Moinuddin Choudhury; Mark R Boyett; Gwilym M Morris
Journal: Arrhythm Electrophysiol Rev Date: 2015-05-30

2. Computational analysis of the human sinus node action potential: model development and effects of mutations.

Authors: Alan Fabbri; Matteo Fantini; Ronald Wilders; Stefano Severi
Journal: J Physiol Date: 2017-04-01 Impact factor: 5.182

Review 3. Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease.

Authors: Oliver Monfredi; Edward G Lakatta
Journal: Cardiovasc Res Date: 2019-09-01 Impact factor: 10.787

4. Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats.

Authors: Toru Kawada; Shuji Shimizu; Kazunori Uemura; Yohsuke Hayama; Hiromi Yamamoto; Toshiaki Shishido; Takuya Nishikawa; Masaru Sugimachi
Journal: J Physiol Sci Date: 2018-09-06 Impact factor: 2.781

Review 5. Minutes, days and years: molecular interactions among different scales of biological timing.

Authors: Diego A Golombek; Ivana L Bussi; Patricia V Agostino
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2014-01-20 Impact factor: 6.237

Review 6. Next-generation pacemakers: from small devices to biological pacemakers.

Authors: Eugenio Cingolani; Joshua I Goldhaber; Eduardo Marbán
Journal: Nat Rev Cardiol Date: 2017-11-16 Impact factor: 32.419

Review 7. Current concepts of anatomy and electrophysiology of the sinus node.

Authors: Cliona Murphy; Ralph Lazzara
Journal: J Interv Card Electrophysiol Date: 2016-05-03 Impact factor: 1.900

8. Electrophysiological heterogeneity of pacemaker cells in the rabbit intercaval region, including the SA node: insights from recording multiple ion currents in each cell.

Authors: Oliver Monfredi; Kenta Tsutsui; Bruce Ziman; Michael D Stern; Edward G Lakatta; Victor A Maltsev
Journal: Am J Physiol Heart Circ Physiol Date: 2017-09-15 Impact factor: 4.733

9. Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

Authors: Michael J Bround; Rich Wambolt; Haoning Cen; Parisa Asghari; Razvan F Albu; Jun Han; Donald McAfee; Marc Pourrier; Nichollas E Scott; Lubos Bohunek; Jerzy E Kulpa; S R Wayne Chen; David Fedida; Roger W Brownsey; Christoph H Borchers; Leonard J Foster; Thibault Mayor; Edwin D W Moore; Michael F Allard; James D Johnson
Journal: J Biol Chem Date: 2016-09-12 Impact factor: 5.157

10. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.

Authors: Michael H Lai; Yuejin Wu; Zhan Gao; Mark E Anderson; Julie E Dalziel; Andrea L Meredith
Journal: Am J Physiol Heart Circ Physiol Date: 2014-08-29 Impact factor: 4.733