Literature DB >> 27142063

Current concepts of anatomy and electrophysiology of the sinus node.

Cliona Murphy1, Ralph Lazzara2.   

Abstract

The sinoatrial node, or sinus node, of humans is the principal pacemaker of the heart. Over the last century, studies have unraveled the complex molecular architecture of the sinus node and the expression of unique ion channels within its specialized myocytes. Aim of this review is to describe the embriology, the anatomy, the histology and the electrophisiology of the sinus node.

Entities:  

Keywords:  Sinus node; Sinus node anatomy; Sinus node physiology

Mesh：

Substances：

Year:  2016        PMID： 27142063     DOI： 10.1007/s10840-016-0137-2

Source DB:  PubMed          Journal:  J Interv Card Electrophysiol        ISSN： 1383-875X            Impact factor:   1.900


  43 in total

Review 1.  Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells.

Authors:  Victor A Maltsev; Edward G Lakatta
Journal:  Heart Lung Circ       Date:  2007-09-10       Impact factor: 2.975

Review 2.  New insights into pacemaker activity: promoting understanding of sick sinus syndrome.

Authors:  Halina Dobrzynski; Mark R Boyett; Robert H Anderson
Journal:  Circulation       Date:  2007-04-10       Impact factor: 29.690

Review 3.  The architecture of the sinus node, the atrioventricular conduction axis, and the internodal atrial myocardium.

Authors:  R H Anderson; S Y Ho
Journal:  J Cardiovasc Electrophysiol       Date:  1998-11

4.  The surgical significance of the atrial branches of the coronary arteries.

Authors:  J Busquet; F Fontan; R H Anderson; S Y Ho; M J Davies
Journal:  Int J Cardiol       Date:  1984-08       Impact factor: 4.164

5.  Molecular mechanism of cAMP modulation of HCN pacemaker channels.

Authors:  B J Wainger; M DeGennaro; B Santoro; S A Siegelbaum; G R Tibbs
Journal:  Nature       Date:  2001-06-14       Impact factor: 49.962

Review 6.  Origin of the sinus impulse.

Authors:  R B Schuessler; J P Boineau; B I Bromberg
Journal:  J Cardiovasc Electrophysiol       Date:  1996-03

7.  Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node.

Authors:  Yue-Kun Ju; Yi Chu; Herve Chaulet; Donna Lai; Othon L Gervasio; Robert M Graham; Mark B Cannell; David G Allen
Journal:  Circ Res       Date:  2007-05-03       Impact factor: 17.367

8.  Pacemaker current (I(f)) in the human sinoatrial node.

Authors:  Arie O Verkerk; Ronald Wilders; Marcel M G J van Borren; Ron J G Peters; Eli Broekhuis; Kayan Lam; Ruben Coronel; Jacques M T de Bakker; Hanno L Tan
Journal:  Eur Heart J       Date:  2007-09-06       Impact factor: 29.983

9.  Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker.

Authors:  Natalie J Chandler; Ian D Greener; James O Tellez; Shin Inada; Hanny Musa; Peter Molenaar; Dario Difrancesco; Mirko Baruscotti; Renato Longhi; Robert H Anderson; Rudolf Billeter; Vinod Sharma; Daniel C Sigg; Mark R Boyett; Halina Dobrzynski
Journal:  Circulation       Date:  2009-03-16       Impact factor: 29.690

10.  The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

Authors:  Willem M H Hoogaars; Alessandra Tessari; Antoon F M Moorman; Piet A J de Boer; Jaco Hagoort; Alexandre T Soufan; Marina Campione; Vincent M Christoffels
Journal:  Cardiovasc Res       Date:  2004-06-01       Impact factor: 10.787
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  4 in total

1.  Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing.

Authors:  Dandan Liang; Jinfeng Xue; Li Geng; Liping Zhou; Bo Lv; Qiao Zeng; Ke Xiong; Huixing Zhou; Duanyang Xie; Fulei Zhang; Jie Liu; Yi Liu; Li Li; Jian Yang; Zhigang Xue; Yi-Han Chen
Journal:  Nat Commun       Date:  2021-01-12       Impact factor: 14.919

2.  Ivabradine increases the high frequency gain ratio in the vagal heart rate transfer function via an interaction with muscarinic potassium channels.

Authors:  Toru Kawada; Hiromi Yamamoto; Tadayoshi Miyamoto; Yohsuke Hayama; Meihua Li; Can Zheng; Kazunori Uemura; Masaru Sugimachi; Keita Saku
Journal:  Physiol Rep       Date:  2021-12

3.  Three-dimensional electroanatomic mapping characteristics of superior vena cava myocardial sleeve and sinoatrial node in patients with atrial fibrillation.

Authors:  Xinguang Chen; Yao Lu; Yanmin Liu; Qiushi Chen; Hongwu Chen; Weizhu Ju; Gang Yang; Yeqian Zhu; Pengcheng Zhao; Jian Zhang; Yangming Mao; Xiaoling Su; Fengxiang Zhang; Minglong Chen
Journal:  Front Cardiovasc Med       Date:  2022-09-07

4.  Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons.

Authors:  Dandan Liang; Zhigang Xue; Jinfeng Xue; Duanyang Xie; Ke Xiong; Huixing Zhou; Fulei Zhang; Xuling Su; Guanghua Wang; Qicheng Zou; Yi Liu; Jian Yang; Honghui Ma; Luying Peng; Chunyu Zeng; Gang Li; Li Wang; Yi-Han Chen
Journal:  Protein Cell       Date:  2021-02-06       Impact factor: 14.870
  4 in total

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