Literature DB >> 3866905

Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea.

J Thompson, P A Skeggs, E Cundliffe.   

Abstract

When DNA fragments from Micromonospora purpurea (the producer of gentamicin) were cloned in Streptomyces lividans, a gentamicin-resistant strain was obtained in which the ribosomes were highly resistant both to gentamicin and to kanamycin. Reconstitution analysis revealed that such resistance resulted from some property of their 16S RNA. Extracts from the clone contained methylase activity which acted on 16S RNA within E. coli 30S ribosomal subunits and rendered them resistant to gentamicin and kanamycin.

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Year:  1985        PMID： 3866905     DOI： 10.1007/bf00425655

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  15 in total

1.  Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis.

Authors:  P A Skeggs; J Thompson; E Cundliffe
Journal:  Mol Gen Genet       Date:  1985

2.  Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea.

Authors:  W Piendl; A Böck; E Cundliffe
Journal:  Mol Gen Genet       Date:  1984

Review 3.  Self defence in antibiotic-producing organisms.

Authors:  E Cundliffe
Journal:  Br Med Bull       Date:  1984-01       Impact factor: 4.291

4.  Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.

Authors:  J Thompson; F Schmidt; E Cundliffe
Journal:  J Biol Chem       Date:  1982-07-25       Impact factor: 5.157

5.  Ribosomal resistance of an istamycin producer, Streptomyces tenjimariensis, to aminoglycoside antibiotics.

Authors:  H Yamamoto; K Hotta; Y Okami; H Umezawa
Journal:  Biochem Biophys Res Commun       Date:  1981-06-16       Impact factor: 3.575

6.  Cloning of the kanamycin resistance gene from a kanamycin-producing Streptomyces species.

Authors:  M M Nakano; H Mashiko; H Ogawara
Journal:  J Bacteriol       Date:  1984-01       Impact factor: 3.490

7.  Cloning of antibiotic resistance and nutritional genes in streptomycetes.

Authors:  C J Thompson; J M Ward; D A Hopwood
Journal:  J Bacteriol       Date:  1982-08       Impact factor: 3.490

8.  Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea.

Authors:  W Piendl; A Böck
Journal:  Antimicrob Agents Chemother       Date:  1982-08       Impact factor: 5.191

9.  Resistance mechanisms of kanamycin-, neomycin-, and streptomycin-producing streptomycetes to aminoglycoside antibiotics.

Authors:  K Hotta; H Yamamoto; Y Okami; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1981-09       Impact factor: 2.649

10.  Characterization in Micromonospora inyoensis of aminoglycoside acetyltransferase activity not previously encountered among actinomycetes.

Authors:  J A Salas; E Cundliffe
Journal:  J Gen Microbiol       Date:  1985-03
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  23 in total

Review 1.  Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

Authors:  L P Kotra; J Haddad; S Mobashery
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

2.  Genetic environments of the rmtA gene in Pseudomonas aeruginosa clinical isolates.

Authors:  Kunikazu Yamane; Yohei Doi; Keiko Yokoyama; Tetsuya Yagi; Hiroshi Kurokawa; Naohiro Shibata; Keigo Shibayama; Haru Kato; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

Review 3.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

Review 4.  Aminoglycosides: An Overview.

Authors:  Kevin M Krause; Alisa W Serio; Timothy R Kane; Lynn E Connolly
Journal:  Cold Spring Harb Perspect Med       Date:  2016-06-01       Impact factor: 6.915

5.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors:  Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

6.  Structural origins of gentamicin antibiotic action.

Authors:  S Yoshizawa; D Fourmy; J D Puglisi
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598

7.  A novel, highly efficient gene-cloning system for Micromonospora strains.

Authors:  M Hasegawa; T Dairi; T Ohta; E Hashimoto
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490

8.  Heterologous Escherichia coli expression, purification and characterization of the GrmA aminoglycoside-resistance methyltransferase.

Authors:  Ivana Moric; Sanja Bajkic; Miloje Savic; Tatjana Ilic Tomic; Graeme L Conn; Branka Vasiljevic
Journal:  Protein J       Date:  2009-10       Impact factor: 2.371

Review 9.  Versatility of aminoglycosides and prospects for their future.

Authors:  Sergei B Vakulenko; Shahriar Mobashery
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

10.  Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

Authors:  Marc Galimand; Patrice Courvalin; Thierry Lambert
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191
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