Literature DB >> 3857598

Identification and characterization of the human type II collagen gene (COL2A1).

K S Cheah, N G Stoker, J R Griffin, F G Grosveld, E Solomon.   

Abstract

The gene contained in the human cosmid clone CosHcol1, previously designated an alpha 1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken alpha 1(II) collagen gene. These data together suggest that CosHcol1 contains the human alpha 1(II) collagen gene COL2A1. The clone appears to contain the whole gene (30 kilobases in length) and will be extremely useful in the study of cartilage development and for identifying those inherited chondrodystrophies in which defects occur in this gene.

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Year:  1985        PMID： 3857598      PMCID： PMC397602          DOI： 10.1073/pnas.82.9.2555

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  42 in total

1.  Confirmation that the type I collagen gene on chromosome 17 is COL1A1 (alpha 1(I), using a human genomic probe.

Authors:  E Solomon; L Hiorns; D Sheer; D Rowe
Journal:  Ann Hum Genet       Date:  1984-01       Impact factor: 1.670

2.  Biosynthetic and structural properties of endothelial cell type VIII collagen.

Authors:  H Sage; B Trüeb; P Bornstein
Journal:  J Biol Chem       Date:  1983-11-10       Impact factor: 5.157

3.  Different levels of glycosylation contribute to the heterogeneity of alpha 1(II) collagen chains derived from a transplantable rat chondrosarcoma.

Authors:  D K Furuto; E J Miller
Journal:  Arch Biochem Biophys       Date:  1983-10-15       Impact factor: 4.013

4.  Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide.

Authors:  L J Sandell; H L Prentice; D Kravis; W B Upholt
Journal:  J Biol Chem       Date:  1984-06-25       Impact factor: 5.157

5.  Synthesis and characterization of cDNA encoding a cartilage-specific short collagen.

Authors:  Y Ninomiya; B R Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

6.  Isolation and characterization of genomic clones corresponding to the human type II procollagen gene.

Authors:  C M Strom; W B Upholt
Journal:  Nucleic Acids Res       Date:  1984-01-25       Impact factor: 16.971

7.  All three chains of 1 alpha 2 alpha 3 alpha collagen from hyaline cartilage resist human collagenase.

Authors:  D R Eyre; J J Wu; D E Woolley
Journal:  Biochem Biophys Res Commun       Date:  1984-02-14       Impact factor: 3.575

8.  Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution.

Authors:  M P Bernard; M L Chu; J C Myers; F Ramirez; E F Eikenberry; D J Prockop
Journal:  Biochemistry       Date:  1983-10-25       Impact factor: 3.162

9.  Isolation of cDNA clones for basal lamina components: type IV procollagen.

Authors:  M Kurkinen; D P Barlow; D M Helfman; J G Williams; B L Hogan
Journal:  Nucleic Acids Res       Date:  1983-09-24       Impact factor: 16.971

10.  Evidence for a dose-dependent inflammatory response to quartz in the rat lung and its significance in early changes in collagen metabolism.

Authors:  S E Sykes; A Morgan; S R Moores; S T Jones; A Holmes; W Davison
Journal:  Environ Health Perspect       Date:  1983-09       Impact factor: 9.031
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  48 in total

1.  R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1).

Authors:  E Takahashi; T Hori; P O'Connell; M Leppert; R White
Journal:  Hum Genet       Date:  1990-11       Impact factor: 4.132

Review 2.  Molecular mechanisms of collagen gene expression.

Authors:  R Raghow; J P Thompson
Journal:  Mol Cell Biochem       Date:  1989-03-16       Impact factor: 3.396

3.  Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?

Authors:  D J Buttle; H Bramwell; A P Hollander
Journal:  Clin Mol Pathol       Date:  1995-08

4.  Covalent genomic DNA modification patterns revealed by denaturing gradient gel blots.

Authors:  Shari L Laprise; Mark R Gray
Journal:  Gene       Date:  2006-12-12       Impact factor: 3.688

5.  IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.

Authors:  L Zhang; J S Pagano
Journal:  Mol Cell Biol       Date:  1997-10       Impact factor: 4.272

6.  Dinucleotide insertion/deletion polymorphism in intron 50 of the COL2A1 gene.

Authors:  G E Tiller; D H Cohn
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

7.  Structural and segregation analysis of the type II collagen gene (COL2A1) in some heritable chondrodysplasias.

Authors:  P Wordsworth; D Ogilvie; L Priestley; R Smith; R Wynne-Davies; B Sykes
Journal:  J Med Genet       Date:  1988-08       Impact factor: 6.318

8.  The pseudo-posterior limiting layer syndrome: a vitreoretinal heredodegeneration with autosomal dominant transmission. Graefe's Arch Clin Exp Ophthalmol (1994) 232:16-24.

Authors:  M P Snead; D K Newmann; A Poulson; J D Scott
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-12       Impact factor: 3.117

9.  Nucleotide sequence of the full length cDNA encoding for human type II procollagen.

Authors:  M W Su; B Lee; F Ramirez; M Machado; W Horton
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971

Review 10.  Gene cloning to clinical trials-the trials and tribulations of a life with collagen.

Authors:  Raymond P Boot-Handford
Journal:  Int J Exp Pathol       Date:  2019-03-26       Impact factor: 1.925
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