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Literature DB >> 30912609

Gene cloning to clinical trials-the trials and tribulations of a life with collagen.

Abstract

This review, based on the BSMB Fell-Muir Lecture I presented in July 2018 at the Matrix Biology Europe Conference in Manchester, gives a personal perspective of my own laboratory's contributions to research into type X collagen, metaphyseal chondrodysplasia type Schmid and potential treatments for this disorder that are currently entering clinical trial. I have tried to set the advances made in the context of the scientific technologies available at the time and how these have changed over the more than three decades of this research.

Entities: Disease

Keywords: ER stress; cartilage; collagen; mouse; pathology; treatment

Mesh：

Substances：
Collagen Type X

Year: 2019 PMID： 30912609 PMCID： PMC6463393 DOI： 10.1111/iep.12311

Source DB: PubMed Journal: Int J Exp Pathol ISSN： 0959-9673 Impact factor: 1.925

56 in total

1. Cloning of human alpha 1(X) collagen DNA and localization of the COL10A1 gene to the q21-q22 region of human chromosome 6.

Authors: S Apte; M G Mattei; B R Olsen
Journal: FEBS Lett Date: 1991-05-06 Impact factor: 4.124

2. Site-directed mutagenesis of human type X collagen. Expression of alpha1(X) NC1, NC2, and helical mutations in vitro and in transfected cells.

Authors: D Chan; Y M Weng; A M Hocking; S Golub; D J McQuillan; J F Bateman
Journal: J Biol Chem Date: 1996-06-07 Impact factor: 5.157

Review 3. Gene cloning to clinical trials-the trials and tribulations of a life with collagen.

Authors: Raymond P Boot-Handford
Journal: Int J Exp Pathol Date: 2019-03-26 Impact factor: 1.925

4. Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia.

Authors: John F Bateman; Richard Wilson; Susanna Freddi; Shireen R Lamandé; Ravi Savarirayan
Journal: Hum Mutat Date: 2005-06 Impact factor: 4.878

5. Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia.

Authors: G A Wallis; B Rash; B Sykes; J Bonaventure; P Maroteaux; B Zabel; R Wynne-Davies; M E Grant; R P Boot-Handford
Journal: J Med Genet Date: 1996-06 Impact factor: 6.318

6. Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes.

Authors: J T Thomas; A P Kwan; M E Grant; R P Boot-Handford
Journal: Biochem J Date: 1991-01-01 Impact factor: 3.857

7. Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.

Authors: Ivan Grskovic; Anna Kutsch; Christian Frie; Gergely Groma; Jacek Stermann; Ursula Schlötzer-Schrehardt; Anja Niehoff; Stephen E Moss; Sabrina Rosenbaum; Ernst Pöschl; Markus Chmielewski; Gunter Rappl; Hinrich Abken; John F Bateman; Kathryn Se Cheah; Mats Paulsson; Bent Brachvogel
Journal: J Bone Miner Res Date: 2012-11 Impact factor: 6.741

8. Steady-state levels of mRNAs coding for the type IV collagen and laminin polypeptide chains of basement membranes exhibit marked tissue-specific stoichiometric variations in the rat.

Authors: R P Boot-Handford; M Kurkinen; D J Prockop
Journal: J Biol Chem Date: 1987-09-15 Impact factor: 5.157

9. Identification and partial characterization of three low-molecular-weight collagenous polypeptides synthesized by chondrocytes cultured within collagen gels in the absence and in the presence of fibronectin.

Authors: G J Gibson; C M Kielty; C Garner; S L Schor; M E Grant
Journal: Biochem J Date: 1983-05-01 Impact factor: 3.857