Literature DB >> 3856877

L1 sequences in HeLa extrachromosomal circular DNA: evidence for circularization by homologous recombination.

R S Jones, S S Potter.   

Abstract

Subcloned probes of the L1 family of repetitive elements were used to isolate L1-carrying clones from a plasmid library of HeLa cell extrachromosomal circular DNA. One clone was analyzed in detail by restriction mapping, cross-hybridization to L1 probes, and base sequence analysis. In addition to approximately the 3' half of a full-sized L1 element, this clone carried 390 base pairs of non-L1 sequence that is single copy in the HeLa genome. A HeLa genomic clone of this unique chromosomal region was isolated and the sequence organization of the circle clone was compared with the linear chromosomal region from which it was ultimately derived. We discuss possible mechanisms of circular DNA formation and propose homologous intrachromosomal recombination between 9-base-pair direct repeats to be most likely in this case.

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Year:  1985        PMID： 3856877      PMCID： PMC397470          DOI： 10.1073/pnas.82.7.1989

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

1.  Isolation and preliminary characterization of the small circular DNA present in African green monkey kidney (BSC-1) cells.

Authors:  R J DeLap; M G Rush; D Zouzias; S Khan
Journal:  Plasmid       Date:  1978-09       Impact factor: 3.466

2.  Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.

Authors:  G E Geier; P Modrich
Journal:  J Biol Chem       Date:  1979-02-25       Impact factor: 5.157

3.  Genome instability in a region of human DNA enriched in Alu repeat sequences.

Authors:  B Calabretta; D L Robberson; H A Barrera-Saldaña; T P Lambrou; G F Saunders
Journal:  Nature       Date:  1982-03-18       Impact factor: 49.962

4.  A rapid boiling method for the preparation of bacterial plasmids.

Authors:  D S Holmes; M Quigley
Journal:  Anal Biochem       Date:  1981-06       Impact factor: 3.365

5.  A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene.

Authors:  J W Adams; R E Kaufman; P J Kretschmer; M Harrison; A W Nienhuis
Journal:  Nucleic Acids Res       Date:  1980-12-20       Impact factor: 16.971

6.  Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing.

Authors:  G F Hollis; P A Hieter; O W McBride; D Swan; P Leder
Journal:  Nature       Date:  1982-03-25       Impact factor: 49.962

7.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

8.  On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

Authors:  A Varshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

9.  Transposition of elements of the 412, copia and 297 dispersed repeated gene families in Drosophila.

Authors:  S S Potter; W J Brorein; P Dunsmuir; G M Rubin
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

10.  Small circular DNA of Drosophila melanogaster: chromosomal homology and kinetic complexity.

Authors:  S W Stanfield; J A Lengyel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205
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  30 in total

1.  The size of small polydisperse circular DNA (spcDNA) in angiofibroma-derived cell cultures from patients with tuberous sclerosis (TSC) differs from that in fibroblasts.

Authors:  K Motejlek; G Assum; W Krone; A K Kleinschmidt
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

2.  The L1 family (KpnI family) sequence near the 3' end of human beta-globin gene may have been derived from an active L1 sequence.

Authors:  A Fujita; M Hattori; O Takenaka; Y Sakaki
Journal:  Nucleic Acids Res       Date:  1987-05-26       Impact factor: 16.971

3.  Conservation in the 5' region of the long interspersed mouse L1 repeat: implications of comparative sequence analysis.

Authors:  E Mottez; P K Rogan; L Manuelidis
Journal:  Nucleic Acids Res       Date:  1986-04-11       Impact factor: 16.971

4.  Multiple mechanisms generate extrachromosomal circular DNA in Chinese hamster ovary cells.

Authors:  S W Stanfield; D R Helinski
Journal:  Nucleic Acids Res       Date:  1986-04-25       Impact factor: 16.971

5.  A repetitive DNA family (Sau3A family) in human chromosomes: extrachromosomal DNA and DNA polymorphism.

Authors:  R Kiyama; H Matsui; M Oishi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

6.  DNA sequence homology between the terminal inverted repeats of Shope fibroma virus and an endogenous cellular plasmid species.

Authors:  C Upton; G McFadden
Journal:  Mol Cell Biol       Date:  1986-01       Impact factor: 4.272

7.  Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1.

Authors:  R Misra; A G Matera; C W Schmid; M G Rush
Journal:  Nucleic Acids Res       Date:  1989-10-25       Impact factor: 16.971

Review 8.  New insights of extrachromosomal DNA in tumorigenesis and therapeutic resistance of cancer.

Authors:  Hui Qiu; Zhi-Ying Shao; Xin Wen; Long-Zhen Zhang
Journal:  Am J Cancer Res       Date:  2020-12-01       Impact factor: 6.166

9.  Recombinant junctions formed by site-specific integration of adeno-associated virus into an episome.

Authors:  C Giraud; E Winocour; K I Berns
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

10.  Heterogeneity in the concerted evolution process of a tandem satellite array in meadow mice (Microtus).

Authors:  W S Modi
Journal:  J Mol Evol       Date:  1993-07       Impact factor: 2.395
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