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Literature DB >> 3821388

Intestinal absorption and fecal excretion of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol by the male Wistar rat.

J Bascoul, N Domergue, J Mourot, G Debry, A Crastes de Paulet.

Abstract

The intestinal absorption of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol, an oxysterol formed by cholesterol autoxidation, has been evaluated in the male Wistar rat. Measurement of the 14C/3H ratio in the serum (by the method of Zilversmit and Hugues) and in the feces showed that a large proportion of the epoxide was absorbed. Epoxide clearance from the blood was very rapid, but its excretion in the stool continued for several days, corresponding to the fraction of the epoxide stored in the animal.

Entities: Chemical Gene Species

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Year: 1986 PMID： 3821388 DOI： 10.1007/bf02535405

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

10 in total

1. The in vitro production of 25- and 26-hydroxycholesterol and their in vivo metabolism.

Authors: D S FREDRICKSON; K ONO
Journal: Biochim Biophys Acta Date: 1956-10

2. Isolation and identification of cholesterol -oxide and other minor sterols in human serum.

Authors: M F Gray; T D Lawrie; C J Brooks
Journal: Lipids Date: 1971-11 Impact factor: 1.880

3. Atherosclerosis and auto-oxidation of cholesterol.

Authors:
Journal: Lancet Date: 1980-05-03 Impact factor: 79.321

4. Implications of the monoclonal character of human atherosclerotic plaques.

Authors: E P Benditt
Journal: Am J Pathol Date: 1977-03 Impact factor: 4.307

5. Further investigations of mutagenic cholesterol preparations.

Authors: G A Ansari; R D Walker; V B Smart; L L Smith
Journal: Food Chem Toxicol Date: 1982-02 Impact factor: 6.023

6. Distribution of 25-hydroxycholesterol in plasma lipoproteins and its role in atherogenesis. A study in squirrel monkeys.

Authors: S K Peng; C B Taylor; E H Mosbach; W Y Huang; J Hill; B Mikkelson
Journal: Atherosclerosis Date: 1982-02 Impact factor: 5.162

3 in total

Intestinal absorption and fecal excretion of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol by the male Wistar rat.

1. The in vitro production of 25- and 26-hydroxycholesterol and their in vivo metabolism.

2. Isolation and identification of cholesterol -oxide and other minor sterols in human serum.

3. Atherosclerosis and auto-oxidation of cholesterol.

4. Implications of the monoclonal character of human atherosclerotic plaques.

5. Further investigations of mutagenic cholesterol preparations.

6. Distribution of 25-hydroxycholesterol in plasma lipoproteins and its role in atherogenesis. A study in squirrel monkeys.

7. Angiotoxicity of oxygenated sterols and possible precursors.

8. Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells: an in vitro study.

9. Mutagenic cholesterol preparations.

10. Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats.

1. Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.

2. Lymphatic absorption of phytosterol oxides in rats.

3. Lymphatic absorption of oxidized cholesterol in rats.