Literature DB >> 386108

Mutagenic cholesterol preparations.

L L Smith, V B Smart, G A Ansari.   

Abstract

Naturally air-aged commercial samples of USP or reagent-grade cholesterol contain components which are mutagenic towards Salmonella typhimurium strains TA1537, TA1538 and TA98. These mutagenic components are associated with the polar cholesterol autoxidation products, but identity of the mutagenic components has not been achieved. Pure crystalline nonmutagenic cholestrol free from autoxidation products becomes mutagenic towards these strains upon heating at 70 degrees in air or following exposure to 60 Co gamma-radiation.

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Year:  1979        PMID： 386108     DOI： 10.1016/0165-1218(79)90074-0

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  8 in total

1.  Analysis and physiologic significance of cholesterol epoxide in animal tissues.

Authors:  H S Black
Journal:  Lipids       Date:  1980-09       Impact factor: 1.880

2.  The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells.

Authors:  Michael C Hall
Journal:  Mol Cell Biochem       Date:  2006-09-16       Impact factor: 3.396

3.  Autoxidation of cholesterol in tallows heated under deep frying conditions: evaluation of oxysterols by GLC and TLC-FID.

Authors:  J Bascoul; N Domergue; M Olle; A Crastes de Paulet
Journal:  Lipids       Date:  1986-06       Impact factor: 1.880

4.  Cholesterol epoxide is a direct-acting mutagen.

Authors:  A Sevanian; A R Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

5.  Intestinal absorption and fecal excretion of 5,6 alpha-epoxy-5 alpha-cholesta-3 beta-ol by the male Wistar rat.

Authors:  J Bascoul; N Domergue; J Mourot; G Debry; A Crastes de Paulet
Journal:  Lipids       Date:  1986-12       Impact factor: 1.880

Review 6.  Mechanisms of oxysterol-induced carcinogenesis.

Authors:  Apinya Jusakul; Puangrat Yongvanit; Watcharin Loilome; Nisana Namwat; Rahul Kuver
Journal:  Lipids Health Dis       Date:  2011-03-09       Impact factor: 3.876

7.  Insulin-tumour interrelationship in EL4 lymphoma or thymoma-bearing mice. I. Alloxan-diabetic or non-diabetic mice.

Authors:  D Yam; A Zilberstein; A Fink; I Nir
Journal:  Br J Cancer       Date:  1990-05       Impact factor: 7.640

Review 8.  Heterotopic tracheal transplants: techniques and applications.

Authors:  A J Klein-Szanto; B C Pal; M Terzaghi; A C Marchok
Journal:  Environ Health Perspect       Date:  1984-06       Impact factor: 9.031
  8 in total

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