| Literature DB >> 3806374 |
Abstract
Three strategies are implemented for controlling serum concentrations by determining individualized dosage regimens. The methods incorporate, respectively, nonlinear least squares parameter estimation, Bayesian maximum a posteriori probability estimation, and a stochastic control procedure that minimizes the expected value of an appropriate therapeutic cost. The performance of the three dose regimen calculation strategies was evaluated using Monte Carlo simulations of a typical therapeutic protocol for tobramycin.Entities:
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Year: 1986 PMID: 3806374 DOI: 10.1007/bf01059659
Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN: 0090-466X