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Literature DB >> 3806081

Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level.

L Nilsson, A Nordberg, J Hardy, P Wester, B Winblad.

Abstract

A technique was developed, which made it possible to study the in vitro release of 3H-acetylcholine (3H-ACh) from human post mortem brain tissue, collected with short post-mortem delay (2,5-22 hours), both from controls and patients with Alzheimer's disease (AD/SDAT). The tritium (3H) release was investigated during potassium stimulation, and AD/SDAT cortical slices were found to release a decreased amount of 3H compared to control brain slices. Physostigmine, 10(-5) and 10(-4) M, has no significant effect on the release of 3H from control slices, while physostigmine 10(-4) M increased the evoked release from AD/SDAT brain slices over threefold, nearly to the control level.

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Year: 1986 PMID： 3806081 DOI： 10.1007/bf01243353

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

25 in total

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Authors: Bettina Maria Foidl; Patricia Do-Dinh; Bianca Hutter-Schmid; Harald R Bliem; Christian Humpel
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