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Literature DB >> 3808458

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains.

Abstract

Nicotinic cholinergic receptors were measured in human frontal cortex using [3H]nicotine and [3H]acetylcholine (in the presence of atropine) as receptor ligands. A parallel marked reduction in number of [3H]nicotine (52%; P less than 0.01) and [3H]acetylcholine (-55%; P less than 0.05) binding was found in the frontal cortex of Alzheimer brains (AD/SDAT) when compared to age-matched control brains. As a comparison the number of muscarinic receptors was quantified using [3H]quinuclidinyl benzilate and found to be significantly increased (+23%; less than 0.01) in AD/SDAT compared to controls.

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Year: 1986 PMID： 3808458 DOI： 10.1016/0304-3940(86)90629-4

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

59 in total

1. Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration.

Authors: R F Muzic; G M Saidel; N Zhu; A D Nelson; L Zheng; M S Berridge
Journal: Med Biol Eng Comput Date: 2000-11 Impact factor: 2.602

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Authors: Joshua D Grill; Jeffrey L Cummings
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Authors: Janine K Cataldo; Judith J Prochaska; Stanton A Glantz
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Authors: E D London; M J Ball; S B Waller
Journal: Neurochem Res Date: 1989-08 Impact factor: 3.996

Review 6. System of synaptic influences on neurons of the neocortex in the presence of a conditioned reflex.

Authors: V M Storozhuk
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Review 7. The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.

Authors: Harald Hampel; M-Marsel Mesulam; A Claudio Cuello; Martin R Farlow; Ezio Giacobini; George T Grossberg; Ara S Khachaturian; Andrea Vergallo; Enrica Cavedo; Peter J Snyder; Zaven S Khachaturian
Journal: Brain Date: 2018-07-01 Impact factor: 13.501

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains.

1. Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration.

2. Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors.

Review 3. Current therapeutic targets for the treatment of Alzheimer's disease.

4. Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation.

5. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia.

Review 6. System of synaptic influences on neurons of the neocortex in the presence of a conditioned reflex.

Review 7. The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.

8. Development and optimization of a novel automated loop method for production of [¹¹C]nicotine.

Review 9. Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

10. Nicotinic systems and cognitive function.

Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains.

1. Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration.

2. Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors.

Review 3. Current therapeutic targets for the treatment of Alzheimer's disease.

4. Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation.

5. Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia.

Review 6. System of synaptic influences on neurons of the neocortex in the presence of a conditioned reflex.

Review 7. The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.

8. Development and optimization of a novel automated loop method for production of [11C]nicotine.

Review 9. Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

10. Nicotinic systems and cognitive function.

8. Development and optimization of a novel automated loop method for production of [¹¹C]nicotine.