Literature DB >> 6148379

Amino acid transport by synaptosomes isolated from post mortem human brain.

J A Hardy, D E Bateman, A M Kidd, J A Edwardson, G B Singh, P R Dodd.   

Abstract

Synaptosomes isolated from post mortem human brain release the transmitter amino acids upon depolarisation. Active preparations can be isolated for up to 24 hours post mortem. The amount of depolarisation-induced release of the transmitter amino acids is correlated with the rate of oxygen uptake. Only when this correlation is taken into consideration would it be possible to detect disease-related changes in presynaptic amino-acid transport systems.

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Year:  1984        PMID： 6148379     DOI： 10.1007/bf01254765

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  11 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

2.  Metabolic and functional studies on post-mortem human brain.

Authors:  J A Hardy; P R Dodd
Journal:  Neurochem Int       Date:  1983       Impact factor: 3.921

3.  Metabolic and secretory processes in nerve-endings isolated from post-mortem brain.

Authors:  P R Dodd; J A Hardy; H F Bradford; G W Bennett; J A Edwardson; B N Harding
Journal:  Neurosci Lett       Date:  1979-01       Impact factor: 3.046

4.  Post-mortem high affinity glutamate uptake in human brain.

Authors:  R Schwarcz; W O Whetsell
Journal:  Neuroscience       Date:  1982-07       Impact factor: 3.590

5.  Synaptosomes prepared from fresh human cerebral cortex; morphology, respiration and release of transmitter amino acids.

Authors:  P Dodd; J A Hardy; A E Oakley; A J Strong
Journal:  Brain Res       Date:  1981-11-16       Impact factor: 3.252

6.  Differential transmitter release from nerve terminals isolated from basal ganglia and substantia nigra.

Authors:  J A Hardy; J S de Belleroche; D Border; H F Bradford
Journal:  J Neurochem       Date:  1980-05       Impact factor: 5.372

7.  Metabolically active synaptosomes can be prepared from frozen rat and human brain.

Authors:  J A Hardy; P R Dodd; A E Oakley; R H Perry; J A Edwardson; A M Kidd
Journal:  J Neurochem       Date:  1983-03       Impact factor: 5.372

8.  A rapid method for preparing synaptosomes: comparison, with alternative procedures.

Authors:  P R Dodd; J A Hardy; A E Oakley; J A Edwardson; E K Perry; J P Delaunoy
Journal:  Brain Res       Date:  1981-12-07       Impact factor: 3.252

9.  On the mechanism by which veratridine causes a calcium-independent release of gamma-aminobutyric acid from brain slices.

Authors:  J Cunningham; M J Neal
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

10.  Use of post-mortem human synaptosomes for studies of metabolism and transmitter amino acid release.

Authors:  J A Hardy; P R Dodd; A E Oakley; A M Kidd; R H Perry; J A Edwardson
Journal:  Neurosci Lett       Date:  1982-12-13       Impact factor: 3.046
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  2 in total

1.  Postmortem- and cryostability of the potassium-evoked release of [3H]5-hydroxytryptamine from rat cerebral cortical miniprisms.

Authors:  C J Fowler; G Thorell; I Fagervall
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

2.  Physostigmine restores 3H-acetylcholine efflux from Alzheimer brain slices to normal level.

Authors:  L Nilsson; A Nordberg; J Hardy; P Wester; B Winblad
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575
  2 in total

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