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Literature DB >> 3804328

Single cell translocations in couples with multiple spontaneous abortions.

Abstract

Single cell translocations have been previously reported to occur in normal lymphocyte cultures. Comparison of the frequency of these in 140 individuals referred for a history of multiple miscarriages and 415 individuals referred for a history of multiple miscarriages and 415 individuals referred for other reasons showed a significantly greater number of single cell translocations in the former group. This group also had a significantly greater number of other types of single cell structural abnormalities. Increased chromosome instability, chromosome mosaicism, residual fetal trophoblasts, and immunological differences are discussed in considering the possible etiology.

Mesh：

Year: 1987 PMID： 3804328 DOI： 10.1007/bf00273833

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

1. Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites.

Authors: R Berger; C D Bloomfield; G R Sutherland
Journal: Cytogenet Cell Genet Date: 1985

2. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.

Authors: M Isobe; J Erikson; B S Emanuel; P C Nowell; C M Croce
Journal: Science Date: 1985-05-03 Impact factor: 47.728

3. Non-random in vitro 7;14 translocations detected in a routine cytogenetic series. 12 examples and their possible significance.

Authors: C Wallace; R Bernstein; M R Pinto
Journal: Hum Genet Date: 1984 Impact factor: 4.132

4. A recurrent structural aberration, t(7;14), in phytohemagglutinin-stimulated lymphocytes.

Authors: L Zech; U Haglund
Journal: Hereditas Date: 1978 Impact factor: 3.271

5. Inhibitory effect of ethidium bromide on mitotic chromosome condensation and its application to high-resolution chromosome banding.

Authors: T Ikeuchi
Journal: Cytogenet Cell Genet Date: 1984

Single cell translocations in couples with multiple spontaneous abortions.

1. Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites.

2. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.

3. Non-random in vitro 7;14 translocations detected in a routine cytogenetic series. 12 examples and their possible significance.

4. A recurrent structural aberration, t(7;14), in phytohemagglutinin-stimulated lymphocytes.

5. Inhibitory effect of ethidium bromide on mitotic chromosome condensation and its application to high-resolution chromosome banding.

6. Human gamma-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7.

7. Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.

8. Karyotype instability with multiple 7/14 and 7/7 rearrangements.

9. Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.

10. Human T-cell receptor alpha-chain genes: location on chromosome 14.

1. On the variable effect of mosaic normal/balanced chromosomal rearrangements in man.