Literature DB >> 3983641

Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.

M Isobe, J Erikson, B S Emanuel, P C Nowell, C M Croce.   

Abstract

The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.

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Year:  1985        PMID： 3983641     DOI： 10.1126/science.3983641

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily.

Authors:  R K Wilson; E Lai; L D Kim; L Hood
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

2.  The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

Authors:  M von Lindern; A Poustka; H Lerach; G Grosveld
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

3.  Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms.

Authors:  P Charmley; A Chao; P Concannon; L Hood; R A Gatti
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

Review 4.  T-cell clones and T-cell receptors.

Authors:  F W Fitch
Journal:  Microbiol Rev       Date:  1986-03

5.  Tissue specificity of chromosomal rearrangements in ataxia-telangiectasia.

Authors:  T L Kojis; R R Schreck; R A Gatti; R S Sparkes
Journal:  Hum Genet       Date:  1989-11       Impact factor: 4.132

6.  Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.

Authors:  A D Duby; J G Seidman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

7.  Probable involvement of immunoglobulin superfamily genes in most recurrent chromosomal rearrangements from ataxia telangiectasia.

Authors:  A Aurias; B Dutrillaux
Journal:  Hum Genet       Date:  1986-03       Impact factor: 4.132

8.  Physical mapping of the human T-cell receptor beta gene complex, using yeast artificial chromosomes.

Authors:  Y Hashim; I Ragoussis; L Kearney; S Tosi; A K So
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

9.  Chromosomal localization of HTLV-1 viral integration sites using in situ hybridization: detection of a novel IL2R fragment.

Authors:  M J Macera; P Szabo; R S Verma
Journal:  Mol Gen Genet       Date:  1992-09

10.  Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7.

Authors:  S Zengerling; L C Tsui; K H Grzeschik; K Olek; J R Riordan; M Buchwald
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025
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