Literature DB >> 3794813

Comparative serum stability of radiochelates for antibody radiopharmaceuticals.

W C Cole, S J DeNardo, C F Meares, M J McCall, G L DeNardo, A L Epstein, H A O'Brien, M K Moi.   

Abstract

Serum incubation of monoclonal antibodies chelate labeled by DTPA, benzyl-EDTA and benzyl-TETA with 111In, 57Co, and 67Cu demonstrated marked differences in their stability. In serum, 111In-benzyl-EDTA-antibody was more stable than 111In-DTPA-antibody. Cobalt-57 or 67Cu chelated antibody were less stable than either 111In chelated antibody; 67Cu was only firmly attached to the antibody as 67Cu-benzyl-TETA-antibody. The relative stability of the radiometal chelated antibodies was paralleled by the relative stability in serum of the radiometal chelates themselves. These in vitro studies suggest that in vivo behavior of metal chelates exposed to a complex protein environment cannot be predicted by classical equilibrium constants.

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Year:  1987        PMID： 3794813

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  14 in total

1.  Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles.

Authors:  Nariman V Amirkhanov; Kaijun Zhang; Mohan R Aruva; Mathew L Thakur; Eric Wickstrom
Journal:  Bioconjug Chem       Date:  2010-04-21       Impact factor: 4.774

Review 2.  Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides.

Authors:  Shuang Liu
Journal:  Adv Drug Deliv Rev       Date:  2008-04-23       Impact factor: 15.470

Review 3.  Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer.

Authors:  A R Fritzberg; R W Berninger; S W Hadley; D W Wester
Journal:  Pharm Res       Date:  1988-06       Impact factor: 4.200

Review 4.  Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities.

Authors:  Zhiliang Cheng; Ajlan Al Zaki; James Z Hui; Vladimir R Muzykantov; Andrew Tsourkas
Journal:  Science       Date:  2012-11-16       Impact factor: 47.728

5.  The remarkable stability of chimeric, sialic acid-derived alpha/delta-peptides in human blood plasma.

Authors:  Jonel P Saludes; Arutselvan Natarajan; Sally J DeNardo; Jacquelyn Gervay-Hague
Journal:  Chem Biol Drug Des       Date:  2010-05       Impact factor: 2.817

6.  Non-cross-bridged tetraazamacrocyclic chelator for stable (64)cu-based radiopharmaceuticals.

Authors:  Ajit V Dale; Darpan N Pandya; Jung Young Kim; Hochun Lee; Yeong Su Ha; Nikunj Bhatt; Jonghee Kim; Jeong Ju Seo; Woonghee Lee; Sung Hong Kim; Young-Ran Yoon; Gwang Il An; Jeongsoo Yoo
Journal:  ACS Med Chem Lett       Date:  2013-07-25       Impact factor: 4.345

7.  A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy.

Authors:  R J Paxton; B G Beatty; M F Hawthorne; A Varadarajan; L E Williams; F L Curtis; C B Knobler; J D Beatty; J E Shively
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

8.  QSAR studies of copper azamacrocycles and thiosemicarbazones: MM3 parameter development and prediction of biological properties.

Authors:  Peter Wolohan; Jeongsoo Yoo; Michael J Welch; David E Reichert
Journal:  J Med Chem       Date:  2005-08-25       Impact factor: 7.446

9.  Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme.

Authors:  E N Atochina; H H Hiemisch; V R Muzykantov; S M Danilov
Journal:  Lung       Date:  1992       Impact factor: 2.584

10.  Reduced bone marrow uptake of indium-111 labelled monoclonal antibody after radiotherapy.

Authors:  H Sakahara; H Onodera; H Kobayashi; Z Yao; I Yamashina; J Konishi
Journal:  Eur J Nucl Med       Date:  1994-11
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