Literature DB >> 24900586

Non-cross-bridged tetraazamacrocyclic chelator for stable (64)cu-based radiopharmaceuticals.

Ajit V Dale1, Darpan N Pandya1, Jung Young Kim2, Hochun Lee3, Yeong Su Ha1, Nikunj Bhatt1, Jonghee Kim1, Jeong Ju Seo4, Woonghee Lee1, Sung Hong Kim5, Young-Ran Yoon4, Gwang Il An2, Jeongsoo Yoo1.   

Abstract

N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with (64)Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.

Entities:  

Keywords:  Bifunctional chelator; copper complex; imaging agent; radiopharmaceutical

Year:  2013        PMID： 24900586      PMCID： PMC4027512          DOI： 10.1021/ml400142s

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  20 in total

1.  Revival of TE2A; a better chelate for Cu(II) ions than TETA?

Authors:  Darpan N Pandya; Jung Young Kim; Jeong Chan Park; Hochun Lee; Prasad B Phapale; Wonjung Kwak; Tae Hyun Choi; Gi Jeong Cheon; Young-Ran Yoon; Jeongsoo Yoo
Journal:  Chem Commun (Camb)       Date:  2010-03-23       Impact factor: 6.222

2.  Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals.

Authors:  Sibaprasad Bhattacharyya; Manish Dixit
Journal:  Dalton Trans       Date:  2011-05-03       Impact factor: 4.390

3.  A practical guide to the construction of radiometallated bioconjugates for positron emission tomography.

Authors:  Brian M Zeglis; Jason S Lewis
Journal:  Dalton Trans       Date:  2011-03-25       Impact factor: 4.390

Review 4.  Copper chelation chemistry and its role in copper radiopharmaceuticals.

Authors:  T J Wadas; E H Wong; G R Weisman; C J Anderson
Journal:  Curr Pharm Des       Date:  2007       Impact factor: 3.116

5.  Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution.

Authors:  Jeongsoo Yoo; David E Reichert; Michael J Welch
Journal:  J Med Chem       Date:  2004-12-16       Impact factor: 7.446

Review 6.  Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals.

Authors:  Brett M Paterson; Paul S Donnelly
Journal:  Chem Soc Rev       Date:  2011-03-15       Impact factor: 54.564

7.  Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator.

Authors:  Jennifer E Sprague; Yijie Peng; Xiankai Sun; Gary R Weisman; Edward H Wong; Samuel Achilefu; Carolyn J Anderson
Journal:  Clin Cancer Res       Date:  2004-12-15       Impact factor: 12.531

8.  An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane-1-ylamino)methyl)benzoic acid, for 64Cu radiopharmaceuticals.

Authors:  Hancheng Cai; Zibo Li; Chiun-Wei Huang; Ryan Park; Anthony H Shahinian; Peter S Conti
Journal:  Nucl Med Biol       Date:  2009-10-12       Impact factor: 2.408

9.  Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research.

Authors:  Carolyn J Anderson; Riccardo Ferdani
Journal:  Cancer Biother Radiopharm       Date:  2009-08       Impact factor: 3.099

10.  Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.

Authors:  Jon D Silversides; Cheryll C Allan; Stephen J Archibald
Journal:  Dalton Trans       Date:  2007-02-01       Impact factor: 4.390
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  3 in total

1.  Phosphonate Pendant Armed Propylene Cross-Bridged Cyclam: Synthesis and Evaluation as a Chelator for Cu-64.

Authors:  Nikunj Bhatt; Nisarg Soni; Yeong Su Ha; Woonghee Lee; Darpan N Pandya; Swarbhanu Sarkar; Jung Young Kim; Hochun Lee; Sun Hee Kim; Gwang Il An; Jeongsoo Yoo
Journal:  ACS Med Chem Lett       Date:  2015-10-20       Impact factor: 4.345

2.  Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myeloma.

Authors:  Clément Bailly; Sébastien Gouard; Michel Chérel; Caroline Bodet-Milin; Marie Lacombe; Patricia Remaud-Le Saëc; Benjamin Chalopin; Mickaël Bourgeois; Nicolas Chouin; Raphaël Tripier; Zakaria Halime; Ferid Haddad; Alain Faivre-Chauvet; Françoise Kraeber-Bodéré
Journal:  Oncotarget       Date:  2018-01-03

3.  What a difference a carbon makes: H₄octapa vs H₄C3octapa, ligands for In-111 and Lu-177 radiochemistry.

Authors:  Eric W Price; Brian M Zeglis; Jacqueline F Cawthray; Jason S Lewis; Michael J Adam; Chris Orvig
Journal:  Inorg Chem       Date:  2014-09-05       Impact factor: 5.165
  3 in total

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