| Literature DB >> 3793501 |
L C Washburn, T T Hwa Sun, J E Crook, B L Byrd, J E Carlton, Y W Hung, Z S Steplewski.
Abstract
Monoclonal antibody 17-1A, which has specificity for colorectal carcinoma, was labeled with 90Y (10-20% radiolabeling yield). Tissue distribution studies in tumor-bearing nude mice were carried out. 90Y-labeled 17-1A showed good uptake in the SW 948 colon carcinoma cell line. However, 90Y-labeled A5C3, a monoclonal antihepatitis virus antibody studied as a control, showed similar uptake in this tumor. Neither antibody was taken up well by a WM-9 melanoma. It is believed that the loss of specificity observed is due to the low specific activity of the 90Y-labeled monoclonal antibody preparations used. This hypothesis is supported by radioimmunoassay data.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3793501 DOI： 10.1016/0883-2897(86)90024-3
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897