Literature DB >> 3789696

Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.

P C Iwen, N G Miller.   

Abstract

Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P less than 0.05) and brain tissue homogenate (P less than 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with dimethyl sulfoxide.

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Year:  1986        PMID： 3789696      PMCID： PMC176493          DOI： 10.1128/AAC.30.4.617

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

Review 1.  A review of the penetration of antibiotics into CSF and its clinical significance.

Authors:  R Norrby
Journal:  Scand J Infect Dis Suppl       Date:  1978

2.  Expanding the definition of the blood-brain barrier to protein.

Authors:  R D Broadwell; M Salcman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

3.  Pemoline levels in brain: enhancement by dimethyl sulfoxide.

Authors:  J J Brink; D G Stein
Journal:  Science       Date:  1967-12-15       Impact factor: 47.728

4.  Inability of dimethyl sulfoxide to increase brain uptake of water-soluble compounds: implications to chemotherapy for brain tumors.

Authors:  N H Greig; D J Sweeney; S I Rapoport
Journal:  Cancer Treat Rep       Date:  1985-03

5.  Morphologic effect of dimethyl sulfoxide on the blood-brain barrier.

Authors:  R D Broadwell; M Salcman; R S Kaplan
Journal:  Science       Date:  1982-07-09       Impact factor: 47.728

6.  Ketoconazole -- a new broad spectrum orally active antimycotic.

Authors:  D Thienpont; J Van Cutsem; F Van Gerven; J Heeres; P A Janssen
Journal:  Experientia       Date:  1979-05-15

7.  Ketoconazole therapy of murine cryptococcal meningitis.

Authors:  P C Craven; J R Graybill; J H Jorgensen
Journal:  Am Rev Respir Dis       Date:  1982-06

8.  Disposition of ketoconazole, an oral antifungal, in humans.

Authors:  C Brass; J N Galgiani; T F Blaschke; R Defelice; R A O'Reilly; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

9.  The effect of dimethyl sulfoxide on tissue distribution of gentamicin.

Authors:  E Rubinstein; A Lev-El
Journal:  Experientia       Date:  1980-01-15

10.  Sensitive bioassay for ketoconazole in serum and cerebrospinal fluid.

Authors:  J H Jorgensen; G A Alexander; J R Graybill; D J Drutz
Journal:  Antimicrob Agents Chemother       Date:  1981-07       Impact factor: 5.191
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  2 in total

1.  Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells.

Authors:  Sameer Agnihotri; Sheila Mansouri; Kelly Burrell; Mira Li; Yasin Mamatjan; Jeff Liu; Romina Nejad; Sushil Kumar; Shahrzad Jalali; Sanjay K Singh; Alenoush Vartanian; Eric Xueyu Chen; Shirin Karimi; Olivia Singh; Severa Bunda; Alireza Mansouri; Kenneth D Aldape; Gelareh Zadeh
Journal:  Clin Cancer Res       Date:  2018-10-15       Impact factor: 12.531

Review 2.  Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae.

Authors:  Alexandre Taravaud; Zineb Fechtali-Moute; Philippe M Loiseau; Sébastien Pomel
Journal:  Clin Transl Sci       Date:  2021-03-01       Impact factor: 4.689
  2 in total

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