Literature DB >> 378852

Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.

E Yarkoni, M B Goren, H J Rapp.   

Abstract

Mycobacterial sulfatides (sulfolipids) in admixture with endotoxin had tumor regressive activity comparable to trehalose-6,6'-dimycolate (TDM) and endotoxin in guinea pigs, but unlike TDM were neither toxic nor granulomagenic and had no antitumor activity in mice. The increased endotoxin lethality in mice pretreated with BCG was not observed in mice pretreated with sulfolipids or TDM instead of BCG.

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Year:  1979        PMID： 378852      PMCID： PMC414309          DOI： 10.1128/iai.24.2.357-362.1979

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.

Authors:  E SUTER; E M KIRSANOW
Journal:  Immunology       Date:  1961-10       Impact factor: 7.397

2.  Constituents of a toxic-lipid obtained from Mycobacterium tuberculosis.

Authors:  H BLOCH; J DEFAYE; E LEDERER; H NOLL
Journal:  Biochim Biophys Acta       Date:  1957-02

3.  Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

4.  Nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor).

Authors:  M Parant; F Audibert; F Parant; L Chedid; E Soler; J Polonsky; E Lederer
Journal:  Infect Immun       Date:  1978-04       Impact factor: 3.441

Review 5.  A guinea pig model for tumor immunology. A summary.

Authors:  H J Rapp
Journal:  Isr J Med Sci       Date:  1973-03

6.  Failure of trehalose-6,6'-dimycolate (P3 or cord factor) to enhance endotoxin lethality in mice.

Authors:  E Yarkoni; M S Meltzer; H J Rapp
Journal:  Infect Immun       Date:  1976-12       Impact factor: 3.441

7.  Toxicity of emulsified trehalose-6,6'-dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1978-06       Impact factor: 3.441

8.  Immunotherapy with an intralesionally administered synthetic cord factor analogue.

Authors:  E Yarkoni; H J Rapp; J Polonsky; E Lederer
Journal:  Int J Cancer       Date:  1978-11-15       Impact factor: 7.396

9.  Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.

Authors:  E Yarkoni; M S Meltzer; H J Rapp
Journal:  Int J Cancer       Date:  1977-06-15       Impact factor: 7.396

10.  Enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate).

Authors:  M Parant; F Parant; L Chedid; J C Drapier; J F Petit; J Wietzerbin
Journal:  J Infect Dis       Date:  1977-05       Impact factor: 5.226
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  3 in total

1.  Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor).

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

2.  Effect of sulfolipid I on trehalose-6,6'-dimycolate (cord factor) toxicity and antitumor activity.

Authors:  E Yarkoni; M B Goren; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

3.  The effect of erythropoietin on normal and neoplastic cells.

Authors:  Steve Elliott; Angus M Sinclair
Journal:  Biologics       Date:  2012-06-27
  3 in total

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