Literature DB >> 326683

Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.

E Yarkoni, M S Meltzer, H J Rapp.   

Abstract

Injection of emulsified trehalose-6,6'-dimycolate (TDM), a mycobacterial glycolipid, into transplants of an established, syngeneic murine fibrosarcoma induced complete regression of tumor in a number of animals. The number of animals in wich tumor regressed completely depended on the amount of oil in the emulsion. The anti-tumor activity of the TDM emulsion containing the highest concentration of oil was equivalent to that of living BCG.

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Year:  1977        PMID： 326683     DOI： 10.1002/ijc.2910190612

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  12 in total

1.  Granuloma formation in lungs of mice after intravenous administration of emulsified trehalose-6,6'-dimycolate (cord factor): reaction intensity depends on size distribution of the oil droplets.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

2.  Influence of oil and Tween concentrations on enhanced endotoxin lethality in mice pretreated with emulsified trehalose-6,6'-dimycolate (cord factor).

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

3.  Effect of sulfolipid I on trehalose-6,6'-dimycolate (cord factor) toxicity and antitumor activity.

Authors:  E Yarkoni; M B Goren; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

4.  Regression of a murine fibrosarcoma after intralesional injection of a synthetic C39 glycolipid related to cord factor.

Authors:  E Yarkoni; H J Rapp; J Polonsky; J Varenne; E Lederer
Journal:  Infect Immun       Date:  1979-11       Impact factor: 3.441

5.  Toxicity of emulsified trehalose-6,6'-dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1978-06       Impact factor: 3.441

6.  Regression of a transplanted guinea pig hepatoma after intralesional injection of an emulsified mixture of endotoxin and mycobacterial sulfolipid.

Authors:  E Yarkoni; M B Goren; H J Rapp
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

7.  Growth inhibition of tumour cells by a liposome-encapsulated, mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate.

Authors:  Y Ohtsubo; M Furukawa; T Imagawa; N Sugimoto; M Ikutoh; S Nakatsugi; Y Katoh; S Shinka; Y Dohi
Journal:  Immunology       Date:  1991-11       Impact factor: 7.397

8.  Immunotherapy of a guinea pig hepatoma with mycobacterial vaccines: comparison of BCG cell walls and cell wall skeletons.

Authors:  E Yarkoni; H J Rapp
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441

9.  Parallel antitumor, granuloma-forming and tumor-necrosis-factor-priming activities of mycoloyl glycolipids from Nocardia rubra that differ in carbohydrate moiety: structure-activity relationships.

Authors:  Y Natsuhara; S Oka; K Kaneda; Y Kato; I Yano
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

10.  Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate.

Authors:  E Yarkoni; E Lederer; H J Rapp
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441
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