| Literature DB >> 3783693 |
A Bernards, L H Van der Ploeg, W C Gibson, P Leegwater, F Eijgenraam, T De Lange, P Weijers, J Calafat, P Borst.
Abstract
To study the evolution of the variant surface glycoprotein (VSG) repertoire of trypanosomes we have analysed the DNA region surrounding the VSG 118 gene in different trypanosome strains. We find a remarkable degree of variation in this area. Downstream from the 118 gene a 5.7 X 10(3) base-pair DNA segment containing a potential VSG gene has been quadruplicated in strain 427 of Trypanosoma brucei, but not in most other strains analysed. The VSG 1.1000 gene, located immediately upstream from the 118 gene in one trypanosome strain, has been cleanly deleted in another. Our results are most easily explained by multiple unequal cross-overs between sister chromatids and are the first indication that sister chromatid exchange occurs in trypanosomes.Entities:
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Year: 1986 PMID： 3783693 DOI： 10.1016/0022-2836(86)90070-7
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469