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Literature DB >> 3783616

Twelve families with fragile X(q27).

Abstract

Through a community study of boys requiring special education for the severely mentally retarded, 12 families were ascertained in which the fragile X was found to be segregating. By assiduous follow up of these families, it was found that in only four of them could male transmission be ruled out from the grandparents' or great grandparents' generation and that the segregation ratios are disturbed.

Entities: Disease Species

Mesh：

Year: 1986 PMID： 3783616 PMCID： PMC1049775 DOI： 10.1136/jmg.23.5.400

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

16 in total

1. Transmission of fragile (X) (q27) site from a male.

Authors: G C Webb; J G Rogers; D B Pitt; J Halliday; T Theobald
Journal: Lancet Date: 1981-11-28 Impact factor: 79.321

2. The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors: S L Sherman; N E Morton; P A Jacobs; G Turner
Journal: Ann Hum Genet Date: 1984-01 Impact factor: 1.670

3. The fragile X chromosome in a large Indian kindred.

Authors: R J Gardner; R D Smart; J M Cornell; L M Merckel; P Beighton
Journal: Clin Genet Date: 1983-04 Impact factor: 4.438

4. Marker X syndrome in an oriental family with probable transmission by a normal male.

Authors: F A Rhoads; A C Oglesby; M Mayer; P A Jacobs
Journal: Am J Med Genet Date: 1982-06

5. Expression in lymphocyte and fibroblast culture of the fragile X chromosome: a new technical approach.

Authors: M G Mattei; J F Mattei; I Vidal; F Giraud
Journal: Hum Genet Date: 1981 Impact factor: 4.132

6. Transmission of fragile (X)(q27) from normal male(s).

Authors: J P Fryns; H van den Berghe
Journal: Hum Genet Date: 1982 Impact factor: 4.132

7. Transmission of the marker X syndrome trait by unaffected males: conclusions from studies of large families.

Authors: U Froster-Iskenius; A Schulze; E Schwinger
Journal: Hum Genet Date: 1984 Impact factor: 4.132

8. Fragile (X)(q27) sites in a pedigree with female carriers showing mild to severe mental retardation.

Authors: G C Webb; J L Halliday; D B Pitt; C G Judge; M Leversha
Journal: J Med Genet Date: 1982-02 Impact factor: 6.318

9. Fragile X trait in a large kindred: transmission also through normal males.

Authors: B C Van Roy; M C De Smedt; R A Raes; J E Dumon; J G Leroy
Journal: J Med Genet Date: 1983-08 Impact factor: 6.318

10. Randomized study for the treatment of adult advanced Hodgkin's disease: mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) versus lomustine, vinblastine, and prednisone.

Authors: H A Liebman; G J Hum; W W Sheehan; V M Ryden; J R Bateman
Journal: Cancer Treat Rep Date: 1983-05

2 in total

1. Between-generation differences in ascertainment and penetrance: relevance to genetic hypotheses in fragile X.

Authors: D Z Loesch; L J Sheffield; D A Hay
Journal: Hum Genet Date: 1993-06 Impact factor: 4.132

2. The frequency of the fragile X chromosome among schoolchildren in Coventry.

Authors: T P Webb; S Bundey; A Thake; J Todd
Journal: J Med Genet Date: 1986-10 Impact factor: 6.318

2 in total