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Literature DB >> 3783615

The frequency of the fragile X chromosome among schoolchildren in Coventry.

Abstract

A population study has been carried out among schoolchildren in the City of Coventry in order to ascertain the frequency of mental retardation associated with the fragile X chromosome. The prevalence of the fragile X mental retardation syndrome in the 11 to 16 year age group (the age of greatest ascertainment) was about 1.0 per 1,000 and therefore indicates that the syndrome is a major cause of mental retardation.

Entities: Disease

Mesh：

Year: 1986 PMID： 3783615 PMCID： PMC1049774 DOI： 10.1136/jmg.23.5.396

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

9 in total

1. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

Authors: G R Sutherland
Journal: Am J Hum Genet Date: 1979-03 Impact factor: 11.025

2. Twelve families with fragile X(q27).

Authors: T Webb; A Thake; J Todd
Journal: J Med Genet Date: 1986-10 Impact factor: 6.318

3. The marker (X) syndrome: a cytogenetic and genetic analysis.

Authors: S L Sherman; N E Morton; P A Jacobs; G Turner
Journal: Ann Hum Genet Date: 1984-01 Impact factor: 1.670

4. A community study of severe mental retardation in the West Midlands and the importance of the fragile X chromosome in its aetiology.

Authors: S Bundey; T P Webb; A Thake; J Todd
Journal: J Med Genet Date: 1985-08 Impact factor: 6.318

5. The diagnosis and frequency of X-linked conditions in a cohort of moderately retarded males with affected brothers.

Authors: J Fishburn; G Turner; A Daniel; R Brookwell
Journal: Am J Med Genet Date: 1983-04

6. Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study.

Authors: H K Blomquist; K H Gustavson; G Holmgren; I Nordenson; U Pålsson-Stråe
Journal: Clin Genet Date: 1983-12 Impact factor: 4.438

7. Nonspecific X-linked mental retardation II: the frequency in British Columbia.

Authors: D S Herbst; J R Miller
Journal: Am J Med Genet Date: 1980

8. Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27).

Authors: G Turner; R Brookwell; A Daniel; M Selikowitz; M Zilibowitz
Journal: N Engl J Med Date: 1980-09-18 Impact factor: 91.245

9. Heritable fragile sites on human chromosomes. XII. Population cytogenetics.

Authors: G R Sutherland
Journal: Ann Hum Genet Date: 1985-05 Impact factor: 1.670

9 in total

31 in total

The frequency of the fragile X chromosome among schoolchildren in Coventry.

1. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.

2. Twelve families with fragile X(q27).

3. The marker (X) syndrome: a cytogenetic and genetic analysis.

4. A community study of severe mental retardation in the West Midlands and the importance of the fragile X chromosome in its aetiology.

5. The diagnosis and frequency of X-linked conditions in a cohort of moderately retarded males with affected brothers.

6. Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study.

7. Nonspecific X-linked mental retardation II: the frequency in British Columbia.

8. Heterozygous expression of X-linked mental retardation and X-chromosome marker fra(X)(q27).

9. Heritable fragile sites on human chromosomes. XII. Population cytogenetics.

1. Fragile X syndrome among children with mental retardation.

2. Frequent small amplifications in the FMR-1 gene in fra(X) families: limits to the diagnosis of 'premutations'.

3. A YAC contig across the fragile X site defines the region of fragility.

4. Prevalence of fragile X syndrome.

Review 5. Non-specific X linked mental retardation.

6. Microdissection of the fragile X region.

7. Social cognition skills among females with fragile X.

8. Prevalence of the fragile X syndrome in four birth cohorts of children of school age.

9. Frequency of the fragile X syndrome in institutionalized mentally retarded females in Japan.

10. Auditory brain-stem responses in the fragile X syndrome.