| Literature DB >> 3783589 |
C B Chapleo, M Myers, P L Myers, J F Saville, A C Smith, M R Stillings, I F Tulloch, D S Walter, A P Welbourn.
Abstract
The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.Entities:
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Year: 1986 PMID： 3783589 DOI： 10.1021/jm00161a024
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446