Literature DB >> 3778456

The glycoprotein nature of A1 adenosine receptors.

K N Klotz, M J Lohse.   

Abstract

A1 adenosine receptors from different tissues and species were photoaffinity labelled and then the carbohydrate content was examined by both enzymatic and chemical treatment. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the labelled membrane receptors shows that neuraminidase treatment alters the electrophoretic mobility of the receptor band indicating the presence of terminal neuraminic acids. Neuraminidase digestion does not influence the binding characteristics of the receptor. The totally deglycosylated receptor protein obtained by chemical treatment has an apparent molecular weight of 32,000.

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Year:  1986        PMID： 3778456     DOI： 10.1016/0006-291x(86)91105-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Lectin binding to the porcine and human ileal receptor of intrinsic factor-cobalamin.

Authors:  O Jokinen; J L Guéant; H Schohn; R Gräsbeck
Journal:  Glycoconj J       Date:  1989       Impact factor: 2.916

2.  Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling.

Authors:  K N Klotz; H Vogt; H Tawfik-Schlieper
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-02       Impact factor: 3.000

3.  2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors.

Authors:  K N Klotz; M J Lohse; U Schwabe; G Cristalli; S Vittori; M Grifantini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

4.  Effect of inhibiting N-glycosylation or oligosaccharide processing on vasoactive intestinal peptide receptor binding activity and structure.

Authors:  A el Battari; P Forget; F Fouchier; P Pic
Journal:  Biochem J       Date:  1991-09-01       Impact factor: 3.857

Review 5.  Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Authors:  K A Jacobson; P J van Galen; M Williams
Journal:  J Med Chem       Date:  1992-02-07       Impact factor: 7.446

Review 6.  Adenosine A1 and A2 receptors: structure--function relationships.

Authors:  P J van Galen; G L Stiles; G Michaels; K A Jacobson
Journal:  Med Res Rev       Date:  1992-09       Impact factor: 12.944
  6 in total

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