Literature DB >> 3774541

Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster.

B L Rogers, M G Sobnosky, G F Saunders.   

Abstract

Human placental lactogen (hPL) and human growth hormone (hGH) are members of a multigene family that share amino acid sequence homology and similarity in gene structure and nucleotide sequence, but differ in both function and expression. To determine the sequence requirements for tissue specific expression recombinant plasmids containing the members of the hPL-hGH multigene family and flanking regions were analyzed by both transient and stable transfection assays. We have identified a transcriptional enhancer in a 1.0 kb region located 2.0 kb downstream of the hPL3 structural gene. This enhancer sequence is not strictly cell-type specific since it functions in cell lines of both placental (JEG-3) and pituitary (18-54,SF) origin. However, its efficiency is several fold higher in placental cells than in pituitary cells.

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Year:  1986        PMID： 3774541      PMCID： PMC311786          DOI： 10.1093/nar/14.19.7647

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  43 in total

1.  A rapid alkaline extraction procedure for screening recombinant plasmid DNA.

Authors:  H C Birnboim; J Doly
Journal:  Nucleic Acids Res       Date:  1979-11-24       Impact factor: 16.971

2.  Growth regulation of cultured human pituitary cells by steroidal and nonsteroidal compounds in defined medium.

Authors:  J H Wyche; W D Noteboom
Journal:  Endocrinology       Date:  1979-06       Impact factor: 4.736

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Authors:  P O Kohler; W E Bridson
Journal:  J Clin Endocrinol Metab       Date:  1971-05       Impact factor: 5.958

4.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors:  P S Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

5.  Expression of two human growth hormone genes in monkey cells infected by simian virus 40 recombinants.

Authors:  G N Pavlakis; N Hizuka; P Gorden; P Seeburg; D H Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

6.  DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

Authors:  M Wigler; A Pellicer; S Silverstein; R Axel; G Urlaub; L Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

7.  Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex.

Authors:  L Katz; D T Kingsbury; D R Helinski
Journal:  J Bacteriol       Date:  1973-05       Impact factor: 3.490

8.  Efficient extraction of RNA from mammalian tissue.

Authors:  M L Frazier; W Mars; D L Florine; R A Montagna; G F Saunders
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

9.  Human prolactin. cDNA structural analysis and evolutionary comparisons.

Authors:  N E Cooke; D Coit; J Shine; J D Baxter; J A Martial
Journal:  J Biol Chem       Date:  1981-04-25       Impact factor: 5.157

10.  Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.

Authors:  F M DeNoto; D D Moore; H M Goodman
Journal:  Nucleic Acids Res       Date:  1981-08-11       Impact factor: 16.971
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  7 in total

1.  Differential expression of human placental growth-hormone variant and chorionic somatomammotropin in culture.

Authors:  B E Nickel; E Kardami; P A Cattini
Journal:  Biochem J       Date:  1990-05-01       Impact factor: 3.857

2.  Identification of a phenotype-specific enhancer in the first intron of the rat collagen II gene.

Authors:  W Horton; T Miyashita; K Kohno; J R Hassell; Y Yamada
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  The chimpanzee GH locus: composition, organization, and evolution.

Authors:  Antonio A Pérez-Maya; Irám P Rodríguez-Sánchez; Pieter de Jong; Michael Wallis; Hugo A Barrera-Saldaña
Journal:  Mamm Genome       Date:  2012-06       Impact factor: 2.957

4.  Functional analysis of elements affecting expression of the beta-actin gene of carp.

Authors:  Z J Liu; B Moav; A J Faras; K S Guise; A R Kapuscinski; P B Hackett
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

5.  Characterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen.

Authors:  P Jacquemin; C Oury; B Peers; A Morin; A Belayew; J A Martial
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

6.  Differential binding of rat pituitary-specific nuclear factors to the 5'-flanking region of pituitary and placental members of the human growth hormone gene family.

Authors:  B E Nickel; M W Nachtigal; M E Bock; P A Cattini
Journal:  Mol Cell Biochem       Date:  1991-08-14       Impact factor: 3.396

7.  CCAAT-enhancer-binding protein β (C/EBPβ) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies complicated by maternal obesity.

Authors:  Hana Vakili; Yan Jin; Savas Menticoglou; Peter A Cattini
Journal:  J Biol Chem       Date:  2013-06-19       Impact factor: 5.157
  7 in total

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