Literature DB >> 3774373

Vaccination of mice against malaria with soluble antigens. I. The effect of detergent, route of injection, and adjuvant.

J H Playfair, J B De Souza.   

Abstract

Mice were vaccinated against lethal blood stage P. yoelii malaria with lysates of parasitised blood prepared in various detergents. Two injections, containing 25 micrograms of protein, of a Triton X-100 lysate gave optimal protection when injected intraperitoneally with saponin as adjuvant. Such lysates provide a starting point for the isolation of potential antigens for vaccination, selected for their protective activity in vivo.

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Year:  1986        PMID： 3774373     DOI： 10.1111/j.1365-3024.1986.tb00857.x

Source DB:  PubMed          Journal:  Parasite Immunol        ISSN： 0141-9838            Impact factor:   2.280


  10 in total

1.  Immunization of mice against blood-stage Plasmodium yoelii malaria with isoelectrically focused antigens and correlation of immunity with T-cell priming in vivo.

Authors:  J B De Souza; J H Playfair
Journal:  Infect Immun       Date:  1988-01       Impact factor: 3.441

2.  Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

Authors:  J H Playfair; J B De Souza
Journal:  Clin Exp Immunol       Date:  1987-01       Impact factor: 4.330

3.  Antibody responses to 43 and 48 kDa antigens of blood-stage Plasmodium berghei in Balb/c mice.

Authors:  Upma Bagai; Anil Pawar; Vineet Kumar
Journal:  J Parasit Dis       Date:  2010-10-08

4.  Two soluble antigens of Plasmodium falciparum induce tumor necrosis factor release from macrophages.

Authors:  J Taverne; C A Bate; D Kwiatkowski; P H Jakobsen; J H Playfair
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

5.  Interferon-gamma as an adjuvant in immunocompromised mice.

Authors:  A W Heath; M E Devey; I N Brown; C E Richards; J H Playfair
Journal:  Immunology       Date:  1989-08       Impact factor: 7.397

6.  The effect of antigen concentration and vaccine regimen on the immunity induced by membrane antigens from the midgut of Boophilus microplus.

Authors:  L A Jackson; J P Opdebeeck
Journal:  Immunology       Date:  1989-10       Impact factor: 7.397

7.  Antibody recognition and isoelectrofocusing of antigens of the malaria parasite Plasmodium yoelii.

Authors:  F A Kironde; A Kumar; A R Nayak; J L Kraikov
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

8.  Malarial parasites induce TNF production by macrophages.

Authors:  C A Bate; J Taverne; J H Playfair
Journal:  Immunology       Date:  1988-06       Impact factor: 7.397

9.  Malaria exoantigens induce T-independent antibody that blocks their ability to induce TNF.

Authors:  C A Bate; J Taverne; A Davé; J H Playfair
Journal:  Immunology       Date:  1990-07       Impact factor: 7.397

10.  Cytokines and antibody subclass associated with protective immunity against blood-stage malaria in mice vaccinated with the C terminus of merozoite surface protein 1 plus a novel adjuvant.

Authors:  J B De Souza; I T Ling; S A Ogun; A A Holder; J H Playfair
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441
  10 in total

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