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Literature DB >> 3113784

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

Abstract

Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneally or subcutaneously. Specific immune responses that were enhanced included antibody, T cell help, and delayed hypersensitivity.

Entities: Chemical Disease Gene Species

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Year: 1987 PMID： 3113784 PMCID： PMC1542557

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

15 in total

1. Immunofluorescence method suitable for large-scale application to malaria.

Authors: A Voller; P O'Neill
Journal: Bull World Health Organ Date: 1971 Impact factor: 9.408

2. Cell-mediated immunity in mice vaccinated against malaria.

Authors: B J Cottrell; J H Playfair; B J De Souza
Journal: Clin Exp Immunol Date: 1978-11 Impact factor: 4.330

3. Reactivity and crossreactivity of mouse helper T cells to malaria parasites.

Authors: J H Playfair; J B De Souza; B J Cottrell
Journal: Immunology Date: 1977-05 Impact factor: 7.397

4. Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite.

Authors: R R Freeman; A J Trejdosiewicz; G A Cross
Journal: Nature Date: 1980-03-27 Impact factor: 49.962

5. Host genotype influences immunomodulation by interferon.

Authors: E De Maeyer; J De Maeyer-Guignard
Journal: Nature Date: 1980-03-13 Impact factor: 49.962

6. The adjuvanticity of interleukin 1 in vivo.

Authors: M J Staruch; D D Wood
Journal: J Immunol Date: 1983-05 Impact factor: 5.422

7. Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells.

Authors: A Zlotnik; R P Shimonkevitz; M L Gefter; J Kappler; P Marrack
Journal: J Immunol Date: 1983-12 Impact factor: 5.422

8. Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen.

Authors: R R Freeman; A A Holder
Journal: Clin Exp Immunol Date: 1983-12 Impact factor: 4.330

9. Antibody responses in mice protected against malaria by vaccination.

Authors: J H Playfair; J B De Souza
Journal: Parasite Immunol Date: 1979 Impact factor: 2.280

10. Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination.

Authors: P G Harte; A Cooke; J H Playfair
Journal: Nature Date: 1983 Mar 17-23 Impact factor: 49.962

19 in total

1. Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens.

Authors: M Troye-Blomberg; E M Riley; L Kabilan; M Holmberg; H Perlmann; U Andersson; C H Heusser; P Perlmann
Journal: Proc Natl Acad Sci U S A Date: 1990-07 Impact factor: 11.205

10. Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: adjuvant effects on induction of protective immunity.

Authors: J Inselburg; I C Bathurst; J Kansopon; G L Barchfeld; P J Barr; R N Rossan
Journal: Infect Immun Date: 1993-05 Impact factor: 3.441

Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice.

1. Immunofluorescence method suitable for large-scale application to malaria.

2. Cell-mediated immunity in mice vaccinated against malaria.

3. Reactivity and crossreactivity of mouse helper T cells to malaria parasites.

4. Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite.

5. Host genotype influences immunomodulation by interferon.

6. The adjuvanticity of interleukin 1 in vivo.

7. Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells.

8. Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen.

9. Antibody responses in mice protected against malaria by vaccination.

10. Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination.

1. Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens.

2. Synthetic peptides from a conserved region of gp120 induce broadly reactive anti-HIV responses.

3. Molecular cloning and expression of cat interferon-gamma.

4. Protective immunity against Plasmodium yoelii malaria induced by immunization with particulate blood-stage antigens.

5. Interactions of interferons in the induction of histocompatibility antigens in mouse fibroblasts and glial cells.

6. T cell source of type 1 cytokines determines illness patterns in respiratory syncytial virus-infected mice.

7. Interferon-gamma as an adjuvant in immunocompromised mice.

8. Primary immune response to liposomal tetanus toxoid in mice: the effect of mediators.

9. Modulation of Klebsiella pneumoniae infection of mice by interferon-gamma.

10. Protective immunity induced in Aotus monkeys by a recombinant SERA protein of Plasmodium falciparum: adjuvant effects on induction of protective immunity.