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Literature DB >> 3754330

Cloning of the gene coding for human L apoferritin.

C Santoro, M Marone, M Ferrone, F Costanzo, M Colombo, C Minganti, R Cortese, L Silengo.

Abstract

A recently reported cDNA clone coding for human promyelocytic L apoferritin, shows some differences with a liver L apoferritin cDNA. We have investigated if these differences are due to the expression of different genes or to an alternative transcription of an unique gene. In this paper we report data suggesting that a single gene is mainly expressed in several tissues examined. This gene has been cloned and characterized. Its sequence shows three introns: the exon sequence is identical to that of cDNA clone isolated from human liver. A minimum of five related pseudogenes have been also analysed. One of them is a processed pseudogene interrupted by an intron-like fragment.

Entities: Gene Species

Mesh：

Substances：
DNA
Ferritins
Apoferritins

Year: 1986 PMID： 3754330 PMCID： PMC339708 DOI： 10.1093/nar/14.7.2863

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

26 in total

1. Suppressive effect of ferritin on in vitro lymphocyte function.

Authors: Y Matzner; C Hershko; A Polliack; A M Konijn; G Izak
Journal: Br J Haematol Date: 1979-07 Impact factor: 6.998

2. A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids.

Authors: L T Chow; J M Roberts; J B Lewis; T R Broker
Journal: Cell Date: 1977-08 Impact factor: 41.582

Review 3. Ferritin: structure, biosynthesis, and role in iron metabolism.

Authors: H N Munro; M C Linder
Journal: Physiol Rev Date: 1978-04 Impact factor: 37.312

4. Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

Authors: D Boyd; C Vecoli; D M Belcher; S K Jain; J W Drysdale
Journal: J Biol Chem Date: 1985-09-25 Impact factor: 5.157

5. Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites.

Authors: B Gronenborn; J Messing
Journal: Nature Date: 1978-03-23 Impact factor: 49.962

6. Electron density map of apoferritin at 2.8-A resolution.

Authors: S H Banyard; D K Stammers; P M Harrison
Journal: Nature Date: 1978-01-19 Impact factor: 49.962

7. The isolation of DNA from agarose gels by electrophoretic elution onto malachite green-polyacrylamide columns.

Authors: B Koller; H Delius; H Bünemann; W Müller
Journal: Gene Date: 1978-11 Impact factor: 3.688

8. On ferritin heterogeneity. Further evidence for heteropolymers.

Authors: P Arosio; T G Adelman; J W Drysdale
Journal: J Biol Chem Date: 1978-06-25 Impact factor: 5.157

9. Cloning of nematode tRNA genes and their expression in the frog oocyte.

Authors: R Cortese; D Melton; T Tranquilla; J D Smith
Journal: Nucleic Acids Res Date: 1978-12 Impact factor: 16.971

10. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

28 in total

1. A second ferritin L subunit is encoded by an intronless gene in the mouse.

Authors: F Renaudie; A K Yachou; B Grandchamp; R Jones; C Beaumont
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. T-cell mitogenesis stimulates the synthesis of a mRNA species coding for a 43-kDa peptide reactive with CM-H-9, a monoclonal antibody specific for placental isoferritin.

Authors: C Moroz; N Shterman; B Kupfer; I Ginzburg
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

Cloning of the gene coding for human L apoferritin.

1. Suppressive effect of ferritin on in vitro lymphocyte function.

2. A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids.

Review 3. Ferritin: structure, biosynthesis, and role in iron metabolism.

4. Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

5. Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites.

6. Electron density map of apoferritin at 2.8-A resolution.

7. The isolation of DNA from agarose gels by electrophoretic elution onto malachite green-polyacrylamide columns.

8. On ferritin heterogeneity. Further evidence for heteropolymers.

9. Cloning of nematode tRNA genes and their expression in the frog oocyte.

10. DNA sequencing with chain-terminating inhibitors.

1. A second ferritin L subunit is encoded by an intronless gene in the mouse.

2. T-cell mitogenesis stimulates the synthesis of a mRNA species coding for a 43-kDa peptide reactive with CM-H-9, a monoclonal antibody specific for placental isoferritin.

3. Position is the critical determinant for function of iron-responsive elements as translational regulators.

4. The location of exon boundaries in the multimeric iron-storage protein ferritin.

5. Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.

6. Ferritin H gene polymorphism in idiopathic hemochromatosis.

7. Do exons code for structural or functional units in proteins?

8. Nucleic acid composition, codon usage, and the rate of synonymous substitution in protein-coding genes.

9. Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

10. Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression.