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Literature DB >> 3754244

Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.

Y Ohba, T Miyaji, M Murakami, S Kadowaki, T Fujita, M Oimomi, H Hatanaka, K Ishikawa, S Baba, K Hitaka.

Abstract

A fast-moving abnormal hemoglobin found in a diabetic patient was identified as beta 140 (H18) Ala----Asp. It comprised about 40% of the total hemoglobin. The beta N-terminal glycation in the abnormal hemoglobin was estimated to be 3 times as much as that in Hb A in the same blood sample. The abnormal hemoglobin was slightly unstable. Oxygen affinity of the stripped hemoglobin was decreased, but that of red cells from the carrier was slightly higher than normal because of the reduced effect of 2,3-diphosphoglycerate.

Entities: Chemical Disease Gene Mutation Species

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Year: 1986 PMID： 3754244 DOI： 10.3109/03630268609046438

Source DB: PubMed Journal: Hemoglobin ISSN： 0363-0269 Impact factor: 0.849

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Cited

9 in total

1. Germline mosaicism for an alanine to valine substitution at residue beta 140 in hemoglobin Puttelange, a new variant with high oxygen affinity.

Authors: H Wajcman; E Girodon; D Promé; M L North; F Plassa; I Duwig; J Kister; J P Bergerat; F Oberling; E Lampert
Journal: Hum Genet Date: 1995-12 Impact factor: 4.132

2. Hb Hope: A Rare Variant of Haemoglobin-Forged a Rise in HbA1c on Immunoturbidimetric Assay.

Authors: Bratati Singh; Debasis Debadatta Behera; Neelam Mehta; Seema Das
Journal: Indian J Clin Biochem Date: 2013-12-03

3. A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA₁c.

Authors: Hisakazu Nishimori; Keiko Harano; Hideho Wada; Satoshi Takano; Shinji Fukuda; Yukihito Takehara; Hiroshi Matsumoto; Isao Kumagai; Mitsune Tanimoto; Sho Takeda
Journal: Int J Hematol Date: 2012-04-08 Impact factor: 2.490

4. Abnormal haemoglobins, Hb Takamatsu and Hb G-Szuhu, detected during the analysis of glycated haemoglobin (HbA1C) by high performance liquid chromatography.

Authors: Y Moriwaki; T Yamamoto; Y Shibutani; T Harano; S Takahashi; T Hada
Journal: J Clin Pathol Date: 2000-11 Impact factor: 3.411

5. Identification of the First Japanese Family Harboring a Novel Hemoglobin Variant "Perpignan", Which Caused Low HbA1c Measurement During Diabetic Follow-Up.

Authors: Mami Nakamura; Ayako Miyazaki; Takayuki Takubo; Yoko Matsuzawa; Jun Saito; Masao Omura; Tetsuo Nishikawa
Journal: Jpn Clin Med Date: 2011-02-02

Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.

1. Germline mosaicism for an alanine to valine substitution at residue beta 140 in hemoglobin Puttelange, a new variant with high oxygen affinity.

2. Hb Hope: A Rare Variant of Haemoglobin-Forged a Rise in HbA1c on Immunoturbidimetric Assay.

3. A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA₁c.

4. Abnormal haemoglobins, Hb Takamatsu and Hb G-Szuhu, detected during the analysis of glycated haemoglobin (HbA1C) by high performance liquid chromatography.

5. Identification of the First Japanese Family Harboring a Novel Hemoglobin Variant "Perpignan", Which Caused Low HbA1c Measurement During Diabetic Follow-Up.

6. A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay.

7. Hemoglobin Himeji and inconsistent hemoglobin A1c values: a case report.

8. HEMOGLOBIN WAYNE VARIANT INTERFERING WITH HEMOGLOBIN A1C MEASUREMENT.

9. Evaluation on the separated effect of 13 hemoglobin variants by a new automatic Hba1c analyzer.