Literature DB >> 22484594

A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA₁c.

Hisakazu Nishimori1, Keiko Harano, Hideho Wada, Satoshi Takano, Shinji Fukuda, Yukihito Takehara, Hiroshi Matsumoto, Isao Kumagai, Mitsune Tanimoto, Sho Takeda.   

Abstract

Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA(1c) level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.

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Year:  2012        PMID： 22484594     DOI： 10.1007/s12185-012-1066-1

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  18 in total

1.  Hb Ube-2 in a diabetic case with an abnormally low HbA1C value.

Authors:  K Hamaguchi; K Harano; T Harano; N Abe; T Sakata
Journal:  Intern Med       Date:  1999-10       Impact factor: 1.271

2.  A new hemoglobin variant, Hb Fukui [alpha139(HC1)Lys --> Asn (AAA --> AAC) (alpha2)].

Authors:  Teruo Harano; Yoshimasa Suetsugu; Keiko Harano; Aung Myint Than; Yin-Feng Hong; Akemi Kuroda
Journal:  Hemoglobin       Date:  2003-05       Impact factor: 0.849

Review 3.  Hemoglobins with high oxygen affinity leading to erythrocytosis. New variants and new concepts.

Authors:  Henri Wajcman; Frederic Galactéros
Journal:  Hemoglobin       Date:  2005       Impact factor: 0.849

4.  Hb Kanagawa [alpha 40(C5)Lys----Met]: a new alpha chain variant with an increased oxygen affinity.

Authors:  H Miyashita; K Hashimoto; H Mohri; T Ohokubo; T Harano; K Harano; K Imai
Journal:  Hemoglobin       Date:  1992       Impact factor: 0.849

5.  Two patients in a family with unstable hemoglobin, Hb Hirosaki: anemia was ameliorated but hemolysis persists after splenectomy.

Authors:  Kenji Shinohara; Yukio Hattori
Journal:  Int J Hematol       Date:  2006-08       Impact factor: 2.490

6.  Hb Himeji or beta 140 (H18) Ala----Asp. A slightly unstable hemoglobin with increased beta N-terminal glycation.

Authors:  Y Ohba; T Miyaji; M Murakami; S Kadowaki; T Fujita; M Oimomi; H Hatanaka; K Ishikawa; S Baba; K Hitaka
Journal:  Hemoglobin       Date:  1986       Impact factor: 0.849

7.  Stereochemistry of cooperative effects in haemoglobin.

Authors:  M F Perutz
Journal:  Nature       Date:  1970-11-21       Impact factor: 49.962

8.  Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia.

Authors:  H B Hamilton; I Iuchi; T Miyaji; S Shibata
Journal:  J Clin Invest       Date:  1969-03       Impact factor: 14.808

9.  Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel.

Authors:  Ayalew Tefferi; Juergen Thiele; Attilio Orazi; Hans Michael Kvasnicka; Tiziano Barbui; Curtis A Hanson; Giovanni Barosi; Srdan Verstovsek; Gunnar Birgegard; Ruben Mesa; John T Reilly; Heinz Gisslinger; Alessandro M Vannucchi; Francisco Cervantes; Guido Finazzi; Ronald Hoffman; D Gary Gilliland; Clara D Bloomfield; James W Vardiman
Journal:  Blood       Date:  2007-05-08       Impact factor: 22.113

10.  Hemoglobin Cowtown (beta 146 HC3 His-Leu): a mutant with high oxygen affinity and erythrocytosis.

Authors:  R G Schneider; J E Bremner; B Brimhall; R T Jones; T B Shih
Journal:  Am J Clin Pathol       Date:  1979-12       Impact factor: 2.493
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