Literature DB >> 3741386

Purification and characterization of dihydrofolate reductase from Mycobacterium phlei.

M Al-Rubeai, J W Dale.   

Abstract

The dihydrofolate reductase from Mycobacterium phlei was purified and characterized; it has an Mr of 15 000 and a pI of 4.8. It is competitively inhibited by both methotrexate and trimethoprim, although the affinity is less than for other bacterial dihydrofolate reductases.

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Year:  1986        PMID： 3741386      PMCID： PMC1146682          DOI： 10.1042/bj2350301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Enzyme inhibition in relation to chemotherapy.

Authors:  W W ACKERMANN; V R POTTER
Journal:  Proc Soc Exp Biol Med       Date:  1949-10

2.  The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor, R388.

Authors:  S G Amyes; J T Smith
Journal:  Eur J Biochem       Date:  1976-01-15

3.  Trimethoprim resistance plasmids of different origin encode different drug-resistant dihydrofolate reductases.

Authors:  B Tennhammar-Ekman; O Sköld
Journal:  Plasmid       Date:  1979-07       Impact factor: 3.466

4.  Inhibitor binding analysis of dihydrofolate reductases from various species.

Authors:  J J Burchall; G H Hitchings
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

Review 5.  Inhibition of folate biosynthesis and function as a basis for chemotherapy.

Authors:  G H Hitchings; J J Burchall
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1965

6.  Classification of trimethoprim-resistant dihydrofolate reductases mediated by R-plasmids using isoelectric focussing.

Authors:  D F Broad; J T Smith
Journal:  Eur J Biochem       Date:  1982-07

7.  Maturation of the head of bacteriophage T4. I. DNA packaging events.

Authors:  U K Laemmli; M Favre
Journal:  J Mol Biol       Date:  1973-11-15       Impact factor: 5.469

8.  Large-scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei.

Authors:  J G Dann; G Ostler; R A Bjur; R W King; P Scudder; P C Turner; G C Roberts; A S Burgen
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

9.  Dihydrofolate reductase hysteresis and its effect of inhibitor binding analyses.

Authors:  D P Baccanari; S S Joyner
Journal:  Biochemistry       Date:  1981-03-31       Impact factor: 3.162

10.  R plasmid dihydrofolate reductase with a dimeric subunit structure.

Authors:  P Novak; D Stone; J J Burchall
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157
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  1 in total

Review 1.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132
  1 in total

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