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Literature DB >> 374108

An adrenergic participation subserving a positive inotropism and chonotropism of prostacyclin on isolated rat atria.

L S Borda, L Cangas, M F Gimeno, A L Gimeno.

Abstract

The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretreatment with 6-OHDopamine.

Entities: Chemical Species

Mesh：

Substances：

Year: 1979 PMID： 374108 DOI： 10.1007/bf01922751

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

16 in total

1. Apparent exception to the all or none law in cardiac muscle.

Authors: W J WHALEN
Journal: Science Date: 1958-02-28 Impact factor: 47.728

2. Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.

Authors: E A de Deckere; D H Nugteren; F Ten Hoor
Journal: Nature Date: 1977-07-14 Impact factor: 49.962

3. Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia.

Authors: A M Lefer; M L Ogletree; J B Smith; M J Silver; K C Nicolaou; W E Barnette; G P Gasic
Journal: Science Date: 1978-04-07 Impact factor: 47.728

4. Effects of monosaccharides, pyruvate, acetate, and butyrate on the developed tension and ATP levels on hypodynamic isolated rat atria.

Authors: J L Lacuara; A L Gimeno; M F Gimeno
Journal: Proc Soc Exp Biol Med Date: 1971-04

5. Correlation of norepinephrine content with observations of adrenergic nerves after a single dose of 6-hydroxydopamine in the rat.

Authors: H Goldman; D Jacobowitz
Journal: J Pharmacol Exp Ther Date: 1971-01 Impact factor: 4.030

6. Prostaglandin-induced preservation of the ischemic myocardium.

Authors: M L Ogletree; A M Lefer
Journal: Circ Res Date: 1978-02 Impact factor: 17.367

7. Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.

Authors: S Bunting; R Gryglewski; S Moncada; J R Vane
Journal: Prostaglandins Date: 1976-12

8. Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.

Authors: E F Ellis; O Oelz; L J Roberts; N A Payne; B J Sweetman; A S Nies; J A Oates
Journal: Science Date: 1976-09-17 Impact factor: 47.728

9. Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin.

Authors: K Schrör; S Moncada; F B Ubatuba; J R Vane
Journal: Eur J Pharmacol Date: 1978-01-01 Impact factor: 4.432

10. Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors: G J Dusting; S Moncada; J R Vane
Journal: Prostaglandins Date: 1977-01

8 in total

1. Stimulating effect of thromboxane B2 on isolated rat atria.

Authors: L Sterin-Borda; L Canga; A L Gimeno
Journal: Experientia Date: 1981-06

2. Hypersensitivity to methoxamine in atria isolated from streptozotocin-induced diabetic rats.

Authors: L Canga; L Sterin-Borda
Journal: Br J Pharmacol Date: 1986-01 Impact factor: 8.739

3. The cardiovascular and platelet effects of epoprostenol (prostacyclin, PGI2) are unaffected by beta-adrenoceptor blockade in man.

Authors: S Hassan; H Pickles; A Fish; C Burke; S Warrington; J O'Grady
Journal: Br J Clin Pharmacol Date: 1982-09 Impact factor: 4.335

4. Effect of phytohemagglutinin-stimulated human lymphocytes on isolated rat atria. Participation of lipoxygenase products of arachidonic acid metabolism.

Authors: L Sterin-Borda; E Borda; S Fink; M M de Bracco
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1983-09 Impact factor: 3.000