Effect of moxalactam on human fecal microflora.

Five healthy male adults received 2 g of moxalactam every 12 h for 7 days. The alterations of fecal microflora were investigated before, during, and after treatment with moxalactam. On day 7 of treatment, the number of total bacteria was decreased in all subjects. There was marked suppression of the obligate anaerobic bacteria and enterobacteria to undetectable levels, but the counts of Streptococcus spp. and Lactobacillus spp. increased. On day 7, two subjects had Clostridium innocuum and Clostridium ramosum in their feces but not Clostridium difficile. On day 7 after treatment, the counts of Streptococcus spp., enterobacteria, Lactobacillus spp., and Clostridium spp. in all subjects were still not normal.