Literature DB >> 3712035

Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies.

P F Sharp, F W Smith, H G Gemmell, D Lyall, N T Evans, D Gvozdanovic, J Davidson, D A Tyrrell, R D Pickett, R D Neirinckx.   

Abstract

A total of nine normal volunteer subjects were studied with three forms of [99mTc] hexamethylpropyleneamineoxime (HM-PAO), a potential cerebral blood flow imaging agent. One, the d,l isomer, showed 4.1% uptake in the brain which remained constant over 8 hr. There was good differentiation between uptake in gray and white matter on tomographic slices. We propose that this agent may allow regional cerebral blood flow imaging to be performed on a routine basis.

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Year:  1986        PMID: 3712035

Source DB:  PubMed          Journal:  J Nucl Med        ISSN: 0161-5505            Impact factor:   10.057


  45 in total

1.  Motor stimulation response by technetium-99m hexamethylpropylene amine oxime split-dose method and single photon emission tomography.

Authors:  P Pantano; V Di Piero; M Ricci; C Fieschi; L Bozzao; G L Lenzi
Journal:  Eur J Nucl Med       Date:  1992

2.  A comparative technetium 99m hexamethylpropylene amine oxime SPET study in different types of dementia.

Authors:  M O Habert; U Spampinato; J L Mas; M L Piketty; M C Bourdel; J de Recondo; P Rondot; S Askienazy
Journal:  Eur J Nucl Med       Date:  1991

3.  99mTc-hexamethylpropylene amine oxime SPECT and X-ray CT in acute cerebral ischaemia.

Authors:  M Feldmann; E Voth; D Dressler; T Henze; K Felgenhauer
Journal:  J Neurol       Date:  1990-12       Impact factor: 4.849

Review 4.  Radiopharmaceuticals: state of the art.

Authors:  A M Verbruggen
Journal:  Eur J Nucl Med       Date:  1990

Review 5.  A brief overview of metal complexes as nuclear imaging agents.

Authors:  Douglas S MacPherson; Kimberly Fung; Brendon E Cook; Lynn C Francesconi; Brian M Zeglis
Journal:  Dalton Trans       Date:  2019-10-07       Impact factor: 4.390

6.  A comparison of Tc-99m HM-PAO and I-123 IMP cerebral SPECT images in Alzheimer's disease and multi-infarct dementia.

Authors:  H G Gemmell; P F Sharp; J A Besson; K P Ebmeier; F W Smith
Journal:  Eur J Nucl Med       Date:  1988

7.  Technetium-99m hexamethylpropylene amine oxime single photon emission tomography of the brain in early Parkinson's disease: correlation with dementia and lateralization.

Authors:  S J Wang; R S Liu; H C Liu; K N Lin; D E Shan; K K Liao; J L Fuh; L S Lee
Journal:  Eur J Nucl Med       Date:  1993-04

8.  Single photon emission computerized tomography in obsessive compulsive disorder: a preliminary study.

Authors:  B L Adams; L B Warneke; A J McEwan; B A Fraser
Journal:  J Psychiatry Neurosci       Date:  1993-05       Impact factor: 6.186

9.  Increased uptake of technetium-99m-hexamethylpropyleneamine oxime related to primary leptomeningeal melanoma.

Authors:  Takao Sagiuchi; Katsumi Ishii; Satoshi Utsuki; Yuuji Asano; Shinya Tsukahara; Shinichi Kan; Kiyotaka Fujii; Kazushige Hayakawa
Journal:  AJNR Am J Neuroradiol       Date:  2002-09       Impact factor: 3.825

10.  Quantification of technetium-99m hexamethylpropylene amine oxime brain uptake in routine clinical practice using calibrated point sources as an external standard: phantom and human studies.

Authors:  A Dobbeleir; R Dierckx
Journal:  Eur J Nucl Med       Date:  1993-08
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