Literature DB >> 369456

Amikacin assay in serum by high-performance liquid chromatography.

S K Maitra, T T Yoshikawa, C M Steyn, L B Guze, M C Schotz.   

Abstract

A high-performance liquid chromatographic method for the quantitative determination of amikacin in serum is described. The antibiotic was separated from serum by adsorption on silica gel. The adsorbed drug was then derivatized with o-phthalaldehyde and eluted with ethanol. The derivatized amikacin was separated by reverse-phase, high-performance liquid chromatography and quantitated by fluorometry. A linear response for serum samples containing amikacin ranging from 1.0 to 15 mug/ml was obtained. Other antibiotics including various aminoglycosides did not interfere with the amikacin assay. Comparison with a standard microbiological assay gave a correlation coefficient of 0.99. This chemical assay is sensitive and specific under the conditions tested and can be performed rapidly.

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Year:  1978        PMID： 369456      PMCID： PMC352573          DOI： 10.1128/AAC.14.6.880

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Improved acetylating radioenzymatic assay of amikacin, tobramycin, and sisomicin in serum.

Authors:  P Stevens; L S Young; W L Hewitt
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

2.  Amikacin: a rapid and sensitive radioimmunoassay.

Authors:  J E Lewis; J C Nelson; H A Elder
Journal:  Antimicrob Agents Chemother       Date:  1975-01       Impact factor: 5.191

3.  High-pressure liquid chromatographic assay of netilmicin in plasma.

Authors:  G W Peng; G G Jackson; W L Chiou
Journal:  Antimicrob Agents Chemother       Date:  1977-12       Impact factor: 5.191

4.  High-pressure liquid-chromatographic method for determination of gentamicin in plasma.

Authors:  G W Peng; M A Gadalla; A Peng; V Smith; W L Chiou
Journal:  Clin Chem       Date:  1977-10       Impact factor: 8.327

5.  Serum gentamicin assay by high-performance liquid chromatography.

Authors:  S K Maitra; T T Yoshikawa; J L Hansen; I Nilsson-Ehle; W J Palin; M C Schotz; L B Guze
Journal:  Clin Chem       Date:  1977-12       Impact factor: 8.327

6.  Column chromatography of amino acids with fluorescence detection.

Authors:  M Roth; A Hampaï
Journal:  J Chromatogr       Date:  1973-08-29

7.  Assay of gentamicin in serum by high-pressure liquid chromatography.

Authors:  J P Anhalt
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

8.  Controlled comparison of amikacin and gentamicin.

Authors:  C R Smith; K L Baughman; C Q Edwards; J F Rogers; P S Lietman
Journal:  N Engl J Med       Date:  1977-02-17       Impact factor: 91.245

9.  Discovery, chemistry, and activity of amikacin.

Authors:  H Kawaguchi
Journal:  J Infect Dis       Date:  1976-11       Impact factor: 5.226

10.  High-performance liquid chromatographic determination of kanamycin.

Authors:  D L Mays; R J Van Apeldoorn; R G Lauback
Journal:  J Chromatogr       Date:  1976-05-12
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  5 in total

1.  Measurement of amikacin in serum by a latex agglutination inhibition test.

Authors:  R F Khabbaz; H C Standiford; D Bernstein; H C Nipper; B A Tatem; U Smalls; G L Drusano; E Caplan
Journal:  J Clin Microbiol       Date:  1985-11       Impact factor: 5.948

2.  Substrate-labeled fluorescent immunoassay for amikacin in human serum.

Authors:  S G Thompson; J F Burd
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

3.  High-pressure liquid chromatography analysis and single-dose disposition of tobramycin in human volunteers.

Authors:  D B Haughey; D M Janicke; M Adelman; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1980-04       Impact factor: 5.191

Review 4.  Serum level monitoring of antibacterial drugs. A review.

Authors:  M Wenk; S Vozeh; F Follath
Journal:  Clin Pharmacokinet       Date:  1984 Nov-Dec       Impact factor: 6.447

Review 5.  Bioanalysis of aminoglycosides using high-performance liquid chromatography.

Authors:  Seth K Amponsah; Joseph A Boadu; Daniel K Dwamena; Kwabena F M Opuni
Journal:  ADMET DMPK       Date:  2022-02-14
  5 in total

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