Literature DB >> 3681988

Evidence for a coiled-coil structure in the spike proteins of coronaviruses.

R J de Groot1, W Luytjes, M C Horzinek, B A van der Zeijst, W J Spaan, J A Lenstra.   

Abstract

The amino acid sequences of the spike proteins from three distantly related coronaviruses have been deduced from cDNA sequences. In the C-terminal half, an homology of about 30% was found, while there was no detectable sequence conservation in the N-terminal regions. Hydrophobic "heptad" repeat patterns indicated the presence of two alpha-helices with predicted lengths of 100 and 50 A, respectively. It is suggested that, in the spike oligomer, these alpha-helices form a complex coiled-coil, resembling the supersecondary structures in two other elongated membrane proteins, the haemagglutinin of influenza virus and the variable surface glycoprotein of trypanosomes.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3681988      PMCID： PMC7131189          DOI： 10.1016/0022-2836(87)90422-0

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  20 in total

1.  Rapid and sensitive protein similarity searches.

Authors:  D J Lipman; W R Pearson
Journal:  Science       Date:  1985-03-22       Impact factor: 47.728

2.  Comparison of the spike precursor sequences of coronavirus IBV strains M41 and 6/82 with that of IBV Beaudette.

Authors:  M M Binns; M E Boursnell; F M Tomley; D K Brown
Journal:  J Gen Virol       Date:  1986-12       Impact factor: 3.891

3.  Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.

Authors:  D C Wiley; I A Wilson; J J Skehel
Journal:  Nature       Date:  1981-01-29       Impact factor: 49.962

4.  Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.

Authors:  I A Wilson; J J Skehel; D C Wiley
Journal:  Nature       Date:  1981-01-29       Impact factor: 49.962

5.  Coronavirus IBV: structural characterization of the spike protein.

Authors:  D Cavanagh
Journal:  J Gen Virol       Date:  1983-12       Impact factor: 3.891

Review 6.  The biology of coronaviruses.

Authors:  S Siddell; H Wege; V Ter Meulen
Journal:  J Gen Virol       Date:  1983-04       Impact factor: 3.891

7.  Nucleotide sequence of the gene encoding the surface projection glycoprotein of coronavirus MHV-JHM.

Authors:  I Schmidt; M Skinner; S Siddell
Journal:  J Gen Virol       Date:  1987-01       Impact factor: 3.891

8.  Cloning and sequencing of the gene encoding the spike protein of the coronavirus IBV.

Authors:  M M Binns; M E Boursnell; D Cavanagh; D J Pappin; T D Brown
Journal:  J Gen Virol       Date:  1985-04       Impact factor: 3.891

9.  Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: activation of cell-fusing activity of virions by trypsin and separation of two different 90K cleavage fragments.

Authors:  L S Sturman; C S Ricard; K V Holmes
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

10.  Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structures.

Authors:  P Metcalf; M Blum; D Freymann; M Turner; D C Wiley
Journal:  Nature       Date:  1987 Jan 1-7       Impact factor: 49.962
View more
  103 in total

1.  Amino acid substitutions within the leucine zipper domain of the murine coronavirus spike protein cause defects in oligomerization and the ability to induce cell-to-cell fusion.

Authors:  Z Luo; A M Matthews; S R Weiss
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Variable sensitivity to substitutions in the N-terminal heptad repeat of Mason-Pfizer monkey virus transmembrane protein.

Authors:  Chisu Song; Eric Hunter
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

Review 3.  The molecular biology of coronaviruses.

Authors:  Paul S Masters
Journal:  Adv Virus Res       Date:  2006       Impact factor: 9.937

4.  Inhibition of human coronavirus NL63 infection at early stages of the replication cycle.

Authors:  Krzysztof Pyrc; Berend Jan Bosch; Ben Berkhout; Maarten F Jebbink; Ronald Dijkman; Peter Rottier; Lia van der Hoek
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

5.  Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein.

Authors:  T M Gallagher; C Escarmis; M J Buchmeier
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

6.  Important role for the transmembrane domain of severe acute respiratory syndrome coronavirus spike protein during entry.

Authors:  Rene Broer; Bertrand Boson; Willy Spaan; François-Loïc Cosset; Jeroen Corver
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

7.  Analysis of murine coronavirus surface glycoprotein functions by using monoclonal antibodies.

Authors:  E Routledge; R Stauber; M Pfleiderer; S G Siddell
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

8.  Identification of an immunodominant linear neutralization domain on the S2 portion of the murine coronavirus spike glycoprotein and evidence that it forms part of complex tridimensional structure.

Authors:  C Daniel; R Anderson; M J Buchmeier; J O Fleming; W J Spaan; H Wege; P J Talbot
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

9.  Identification and characterization of genetically divergent members of the newly established family Mesoniviridae.

Authors:  Florian Zirkel; Hanna Roth; Andreas Kurth; Christian Drosten; John Ziebuhr; Sandra Junglen
Journal:  J Virol       Date:  2013-03-27       Impact factor: 5.103

10.  Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor.

Authors:  Gregory J Babcock; Diana J Esshaki; William D Thomas; Donna M Ambrosino
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.