Literature DB >> 7464906

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.

I A Wilson, J J Skehel, D C Wiley.   

Abstract

The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of alpha-helices extends 76 A from the membrane and a globular region of antiparallel beta-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 A distally and folding back to enter the membrane.

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Year:  1981        PMID： 7464906     DOI： 10.1038/289366a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  898 in total

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