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Literature DB >> 3661677

Immunohistochemical localization of metallothionein in human thyroid tumors.

Abstract

High levels of metallothionein (MT) are present in the developing mammalian liver; however, a remarkable decrease is observed during postnatal life after weaning. This developmental profile is similar to that of certain oncofetal gene products such as alpha-fetoprotein, which is used as a tumor marker. This study deals with the reexpression of MT genes in thyroid tumors. With an immunohistochemical method, the presence of MT was investigated in tissue sections of normal and neoplastic human thyroid glands. Tissue sections of 34 thyroid tumors and 10 normal human thyroid glands were studied by means of the peroxidase-antiperoxidase method. MT was localized in 31 of the thyroid gland tumors. MT was also present in two of the normal thyroid glands. These findings indicate that although high levels of MT are mainly found in the fetal liver, it may also be expressed actively in certain human thyroid neoplastic tissues, and occasionally in normal thyroid tissue.

Entities: Disease Species

Mesh：

Substances：
Metallothionein

Year: 1987 PMID： 3661677 PMCID： PMC1899699

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

22 in total

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Journal: Biochem Biophys Res Commun Date: 1978-10-30 Impact factor: 3.575

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Journal: Toxicol Appl Pharmacol Date: 1979-03-30 Impact factor: 4.219

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Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

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Journal: J Biol Chem Date: 1978-01-25 Impact factor: 5.157

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Journal: Biochem J Date: 1975-09 Impact factor: 3.857

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Journal: Am J Physiol Date: 1978-03

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Journal: J Biol Chem Date: 1980-06-10 Impact factor: 5.157

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Authors: S Onosaka; K S Min; C Fukuhara; K Tanaka; S Tashiro; I Shimizu; M Furuta; T Yasutomi; K Kobashi; K Yamamoto
Journal: Toxicology Date: 1986-03 Impact factor: 4.221

18 in total

1. Localization of zinc and metallothionein in the rat bladder epithelium during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

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Journal: Urol Res Date: 1996

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Journal: Clin Rheumatol Date: 1998 Impact factor: 2.980

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Journal: Biol Trace Elem Res Date: 1991-09 Impact factor: 3.738

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Journal: Virchows Arch A Pathol Anat Histopathol Date: 1989

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Authors: G Ohshio; T Imamura; N Okada; Z H Wang; K Yamaki; T Kyogoku; H Suwa; H Yamabe; M Imamura
Journal: J Cancer Res Clin Oncol Date: 1996 Impact factor: 4.553

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Journal: Virchows Arch A Pathol Anat Histopathol Date: 1993

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Authors: Ni Wang; Chao-Ran Dong; Rong Jiang; Cui Tang; Lei Yang; Qi-Feng Jiang; George G Chen; Zhi-Min Liu
Journal: Int J Clin Exp Pathol Date: 2013-12-15

8. Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: identification of a novel nonsilent metallothionein-1H mutant variant.

Authors: Siew-Kian Tai; Owen June-Keong Tan; Vincent Tak-Kwong Chow; Rongxian Jin; J Louise Jones; Puay-Hoon Tan; Anita Jayasurya; Boon-Huat Bay
Journal: Am J Pathol Date: 2003-11 Impact factor: 4.307

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Journal: Biochem J Date: 1993-12-01 Impact factor: 3.857

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Journal: Virchows Arch A Pathol Anat Histopathol Date: 1993