| Literature DB >> 3952754 |
S Onosaka, K S Min, C Fukuhara, K Tanaka, S Tashiro, I Shimizu, M Furuta, T Yasutomi, K Kobashi, K Yamamoto.
Abstract
Concentration of metallothionein in the malignant and non-malignant tissues of the human liver was determined by the Cd-hem method. The concentration of metallothionein was high in the non-malignant tissue (471 +/- 306 micrograms/g). Metallothionein in the non-malignant tissue was mainly Zn-thionein and metallothionein-bound Zn was a major chemical form of Zn in the non-malignant tissue. The concentration of metallothionein in the malignant tissue was 75.6 +/- 79.6 micrograms/g, and significantly lower than that in the nonmalignant tissue. A strong, positive relationship was observed between the Zn and metallothionein concentrations, and the regression equation was MT (microgram/g) = -94.7 + 11.9 Zn (micrograms/g).Entities:
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Year: 1986 PMID： 3952754 DOI： 10.1016/0300-483x(86)90142-3
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221