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Literature DB >> 1201001

The induction of metallothionein in rat liver by zinc injection and restriction of food intake.

Abstract

The isolation of two forms of hepatic zinc-thioneins after either zinc injection into rats or partial restriction of their food intake is described. The proteins differed slightly in their amino acid composition and electrophoretic mobilities. Increases in liver zinc content after both treatments were synchronous with, and associated almost completely with, increased zinc-binding to these proteins. The time-course for the appearance and disappearance of the zinc proteins is shown. It is suggested that metallothionein is involved in the normal metabolism of zinc, perhaps in some temporary storage or detoxication capacity.

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Year: 1975 PMID： 1201001 PMCID： PMC1165681 DOI： 10.1042/bj1490733

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Properties of the apoprotein and role of copper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase.

Authors: G Rotilio; L Calabrese; F Bossa; D Barra; A F Agrò; B Mondovì
Journal: Biochemistry Date: 1972-05-23 Impact factor: 3.162

3. Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

Authors: J H Kägi; S R Himmelhoch; P D Whanger; J L Bethune; B L Vallee
Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

4. Binding of cadmium ions by rat liver and kidney.

Authors: M Webb
Journal: Biochem Pharmacol Date: 1972-10-15 Impact factor: 5.858

5. Characterization of Cd, Zn-thionein (metallothionein) isolated from rat and chicken liver.

Authors: U Weser; H Rupp; F Donay; F Linnemann; W Voelter; W Voetsch; G Jung
Journal: Eur J Biochem Date: 1973-11-01

6. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

Authors: J M McCord; I Fridovich
Journal: J Biol Chem Date: 1969-11-25 Impact factor: 5.157

7. Binding of mercury in the rat: studies using 203HgCl2 and gel filtration.

Authors: M Jakubowski; J Piotrowski; B Trojanowska
Journal: Toxicol Appl Pharmacol Date: 1970-05 Impact factor: 4.219

8. Hepatic copper-and zinc-binding proteins in ruminants. 1. Distribution of Cu and Zn among soluble proteins of livers of varying Cu and Zn content.

Authors: I Bremner; R B Marshall
Journal: Br J Nutr Date: 1974-09 Impact factor: 3.718

9. Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium.

Authors: J K Piotrowski; B Trojanowska; J M Wiśniewska-Knypl; W Bolanowska
Journal: Toxicol Appl Pharmacol Date: 1974-01 Impact factor: 4.219

10. Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein.

Authors: M Giralt; T Gasull; J Hernandez; A Garcia; J Hidalgo
Journal: Biometals Date: 1993 Impact factor: 2.949

The induction of metallothionein in rat liver by zinc injection and restriction of food intake.

1. Protein measurement with the Folin phenol reagent.

2. Properties of the apoprotein and role of copper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase.

3. Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

4. Binding of cadmium ions by rat liver and kidney.

5. Characterization of Cd, Zn-thionein (metallothionein) isolated from rat and chicken liver.

6. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).

7. Binding of mercury in the rat: studies using 203HgCl2 and gel filtration.

8. Hepatic copper-and zinc-binding proteins in ruminants. 1. Distribution of Cu and Zn among soluble proteins of livers of varying Cu and Zn content.

9. Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium.

10. Separation of two forms of rabbit metallothionein by isoelectric focusing.

1. The effect of anesthetic agents on zinc metabolism in the rat liver.

2. Properties of cod metallothionein, its presence in different tissues and effects of Cd and Zn treatment.

3. Histological demonstration of immunoreactive zinc metallothionein in liver and ileum of rat and man.

4. Immunochemical detection of metallothionein in specific epithelial cells of rat organs.

5. Induction of rat liver metallothionein mRNA and its distribution between free and membrane-bound polyribosomes.

6. Effect of zinc status of rats on the synthesis and degradation of copper-induced metallothioneins.

7. Zinc-binding protein in the livers of neonatal, normal and partially hepatectomized rats.

8. Isolation of (copper, zinc)-thioneins from the livers of copper-injected rats.

9. Fate and comparative toxicity of metallothioneins with differing Cd/Zn ratios in rat kidney.

10. Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein.