Literature DB >> 363442

Prostacyclin-like activity of endothelium and subendothelium - important for atherosclerosis?

K Silberbauer, H Sinzinger, M Winter, W Feigl, F Ring.   

Abstract

Morphological control of Moncada's bioassay for prostacyclin (PG I2) activity measurement shows that the activity depends not only on endothelium, but in important amounts on subendothelial tissue too. Therefore, it can be concluded that platelet thrombus formation after endothelial cell injury does not depend only on the PG I2-producing ability of the tissue.

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Year:  1978        PMID： 363442     DOI： 10.1007/bf01932360

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  Quantitative morphological investigations on smooth muscle cells in vascular surgical specimens and their clinical importance.

Authors:  W Feigl; H Sinzinger; O Wagner; C Leithner
Journal:  Experientia       Date:  1975-11-15

2.  Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart.

Authors:  E A de Deckere; D H Nugteren; F Ten Hoor
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

3.  Experimental aortic intimal thickening. I. Morphology and source of intimal cells.

Authors:  W S Webster; S P Bishop; J C Geer
Journal:  Am J Pathol       Date:  1974-08       Impact factor: 4.307

4.  Prostacyclin and atherosclerosis in rats.

Authors:  S Villa; M Mysliwiec; G de Galtano
Journal:  Lancet       Date:  1977-06-04       Impact factor: 79.321

5.  Prostacyclin production by vascular smooth-muscle cells.

Authors:  K Silberbauer; H Sinzinger; M Winter
Journal:  Lancet       Date:  1978-06-24       Impact factor: 79.321

6.  Repair in arterial tissue. A scanning electron microscopic (SEM) and light microscopic study on the endothelium of rabbit thoracic aorta following a single dilatation injury.

Authors:  B C Christensen; C Garbarsch
Journal:  Virchows Arch A Pathol Pathol Anat       Date:  1973-08-09

7.  Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog). A comparative study.

Authors:  Z Sinakos; J P Caen
Journal:  Thromb Diath Haemorrh       Date:  1967-02-28

8.  A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.

Authors:  S Moncada; R J Gryglewski; S Bunting; J R Vane
Journal:  Prostaglandins       Date:  1976-11

9.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

10.  Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.

Authors:  S Moncada; E A Higgs; J R Vane
Journal:  Lancet       Date:  1977-01-01       Impact factor: 79.321
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  3 in total

1.  Relation between fibrinolytic activity and prostacyclin generation of atherosclerotic artery and dacron prosthetic graft.

Authors:  H Sinzinger; K Silberbauer; M Winter; W Auerswald
Journal:  Experientia       Date:  1979-06-15

Review 2.  Prostaglandin I2 (prostacyclin).

Authors:  J G Kelton; M A Blajchman
Journal:  Can Med Assoc J       Date:  1980-01-26       Impact factor: 8.262

3.  Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat.

Authors:  S E Belo; J Talesnik
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739
  3 in total

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