Literature DB >> 6988063

Prostaglandin I2 (prostacyclin).

J G Kelton, M A Blajchman.   

Abstract

Prostaglandin I2 (PGI2), or prostacyclin, is a recently discovered prostaglandin that affects many organ systems. It is both a potent inhibitor of platelet aggregation and a powerful vasodilator. The recent demonstration that it is the main prostaglandin synthesized by the blood vessel wall suggests that it may play an important role in limiting platelet-mediated thrombosis. However, despite considerable investigation, the exact physiological role of PGI2 has yet to be elucidated.

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Year:  1980        PMID： 6988063      PMCID： PMC1801769     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  48 in total

Review 1.  Platelet function in health and disease.

Authors:  J Hirsh; J C Doery
Journal:  Prog Hematol       Date:  1971

Review 2.  Emerging concepts of platelet function.

Authors:  D Deykin
Journal:  N Engl J Med       Date:  1974-01-17       Impact factor: 91.245

3.  Stimulation of human platelet adenylate cyclase by prostaglandin D2.

Authors:  D C Mills; D E Macfarlane
Journal:  Thromb Res       Date:  1974-09       Impact factor: 3.944

4.  The inhibition of platelet aggregation by an aorta intima extract.

Authors:  A P Heyns; D J van den Berg; G M Potgieter; F P Retief
Journal:  Thromb Diath Haemorrh       Date:  1974-12-31

5.  Aspects of prostaglandin function in the lung (first of two parts).

Authors:  A A Mathé; P Hedqvist; K Strandberg; C A Leslie
Journal:  N Engl J Med       Date:  1977-04-14       Impact factor: 91.245

6.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors:  R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal:  Prostaglandins       Date:  1976-11

7.  Modulation of human platelet adenylate cyclase by prostacyclin (PGX).

Authors:  R R Gorman; S Bunting; O V Miller
Journal:  Prostaglandins       Date:  1977-03

8.  Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-01

9.  Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.

Authors:  S Moncada; E A Higgs; J R Vane
Journal:  Lancet       Date:  1977-01-01       Impact factor: 79.321

10.  The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets.

Authors:  D C Mills; J B Smith
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857
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  7 in total

1.  Amblyomma americanum tick saliva insulin-like growth factor binding protein-related protein 1 binds insulin but not insulin-like growth factors.

Authors:  Ž M Radulović; L M Porter; T K Kim; M Bakshi; A Mulenga
Journal:  Insect Mol Biol       Date:  2015-06-25       Impact factor: 3.585

Review 2.  Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs.

Authors:  Melissa Gabbs; Shan Leng; Jessay G Devassy; Md Monirujjaman; Harold M Aukema
Journal:  Adv Nutr       Date:  2015-09-15       Impact factor: 8.701

3.  Endogenous synthesis of prostacyclin was positively regulated during the maturation phase of cultured adipocytes.

Authors:  Mohammad Sharifur Rahman; Ferdous Khan; Pinky Karim Syeda; Kohji Nishimura; Mitsuo Jisaka; Tsutomu Nagaya; Fumiaki Shono; Kazushige Yokota
Journal:  Cytotechnology       Date:  2013-07-25       Impact factor: 2.058

4.  Sarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes.

Authors:  Rafael Opazo; Bárbara Angel; Carlos Márquez; Lydia Lera; Gustavo R Cardoso Dos Santos; Gustavo Monnerat; Cecilia Albala
Journal:  Metabolomics       Date:  2021-09-08       Impact factor: 4.290

5.  Morphology of irradiated microvasculature: a combined in vivo and electron-microscopic study.

Authors:  K Narayan; W J Cliff
Journal:  Am J Pathol       Date:  1982-01       Impact factor: 4.307

6.  Adenine attenuates the Ca(2+) contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells.

Authors:  Toshihiko Fukuda; Takahiro Kuroda; Miki Kono; Mai Hyoguchi; Satoshi Tajiri; Mitsuru Tanaka; Yoshinori Mine; Toshiro Matsui
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-06-18       Impact factor: 3.000

Review 7.  Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception.

Authors:  Yongwoo Jang; Minseok Kim; Sun Wook Hwang
Journal:  J Neuroinflammation       Date:  2020-01-22       Impact factor: 8.322
  7 in total

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