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Literature DB >> 3627109

Tuftsin induced tumor necrosis activity.

Abstract

Tuftsin induced tumor necrosis activity was investigated. The activity was found in mice serum several days after i.p. injection of tuftsin. Further experiments with adhering peritoneal and spleen cells indicated that macrophages were the source of the observed activity. The same effect was observed when promyelocytic leukemia cells (HL60) were stimulated with different concentrations of the peptide. These showed yet another possible mechanism for tuftsin antineoplastic activity.

Entities: Disease Species

Mesh：

Substances：

Year: 1987 PMID： 3627109 DOI： 10.1007/BF00229905

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

41 in total

1. Solid-phase tuftsin (Thr-Lys-Pro-Arg) synthesis: deprotection and resin cleavage with trifluoromethane sulfonic acid.

Authors: M K Chaudhuri; V A Najjar
Journal: Anal Biochem Date: 1979-05 Impact factor: 3.365

2. Molecular mechanisms in tumor-cell killing by activated macrophages.

Authors: D O Adams; C F Nathan
Journal: Immunol Today Date: 1983-06

3. A new phagocytosis-stimulating tetrapeptide hormone, tuftsin, and its role in disease.

Authors: V A Najjar; A Constantopoulos
Journal: J Reticuloendothel Soc Date: 1972-08

Review 4. Tuftsin: a hormone-like tetrapeptide with antimicrobial and antitumor activities.

Authors: K Nishioka; A A Amoscato; G F Babcock
Journal: Life Sci Date: 1981-03-09 Impact factor: 5.037

5. Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation.

Authors: K Kumagai; K Itoh; S Hinuma; M Tada
Journal: J Immunol Methods Date: 1979 Impact factor: 2.303

6. Inhibition by tuftsin of Rauscher virus leukemia development in mice.

Authors: A Knyszynski; P Gottlieb; M Fridkin
Journal: J Natl Cancer Inst Date: 1983-07 Impact factor: 13.506

7. The antineoplastic effects of tuftsin and tuftsinyltuftsin on B16/5B melanoma and L1210 cells.

Authors: V A Najjar; L Linehan; D Konopińska
Journal: Ann N Y Acad Sci Date: 1983 Impact factor: 5.691

8. Effects of murine tumor necrosis factor on heterotransplanted human tumors.

Authors: L Helson; C Helson; S Green
Journal: Exp Cell Biol Date: 1979

9. Rabbit tumor necrosis factor: mechanism of action.

Authors: M R Ruff; G E Gifford
Journal: Infect Immun Date: 1981-01 Impact factor: 3.441

10. Tumour-necrosis factor from the rabbit. II. Production by monocytes.

Authors: N Matthews
Journal: Br J Cancer Date: 1978-08 Impact factor: 7.640

4 in total

1. The characteristics of purified HL60 tuftsin receptors.

Authors: N J Bump; V A Najjar; J Reichler
Journal: Mol Cell Biochem Date: 1990-01-18 Impact factor: 3.396

2. Augmentation of antileishmanial efficacy of miltefosine in combination with tuftsin against experimental visceral leishmaniasis.

Authors: Nishi Shakya; Shraddha A Sane; Wahajul Haq; Suman Gupta
Journal: Parasitol Res Date: 2012-03-06 Impact factor: 2.289

3. Microglia/macrophages promote glioma progression.

Authors: Haiyan Zhai; Frank L Heppner; Stella E Tsirka
Journal: Glia Date: 2010-12-29 Impact factor: 7.452

4. The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro.

Authors: E Cillari; F Arcoleo; M Dieli; R D'Agostino; G Gromo; F Leoni; S Milano
Journal: Infect Immun Date: 1994-06 Impact factor: 3.441

4 in total