| Literature DB >> 36238867 |
Antonina V Popova1, Mykhaylo S Frasinyuk1,2,3, Svitlana P Bondarenko4, Wen Zhang2,5, Yanqi Xie2,3, Zachary M Martin2,3, Xianfeng Cai2,5, Michael V Fiandalo6, James L Mohler6, Chunming Liu2,5, David S Watt2,3,5, Vitaliy M Sviripa3,7.
Abstract
An efficient method for regioselective synthesis of C-7 Mannich bases of 6-hydroxyaurones was accomplished by the N,N-dialkylaminomethylation using aminals prepared from dimethylamine, dipropylamine, bis(2-methoxyethyl)amine, N-methylbutylamine, N-methylbenzylamine, morpholine, piperidine, and 1-methylpiperazine. Further transformation of 7-(N,N-dialkylamino)methyl group in these aurones led to formation of C-7 acetoxymethyl and methoxymethyl derivatives of 6-hydroxyaurones, some of which showed promising inhibition of PC-3 prostate cancer cell proliferation in the high nanomolar to low micromolar range that exceeded that of cisplatin.Entities:
Keywords: 6-hydroxyаurones; Mannich base; aminomеthylation; prostate cancer
Year: 2018 PMID： 36238867 PMCID： PMC9555813 DOI： 10.1007/s11696-018-0485-8
Source DB: PubMed Journal: Chem Zvesti ISSN： 0366-6352 Impact factor: 2.146