| Literature DB >> 18436348 |
Rong Sheng1, Yu Xu, Chunqi Hu, Jing Zhang, Xiao Lin, Jingya Li, Bo Yang, Qiaojun He, Yongzhou Hu.
Abstract
A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test.Entities:
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Year: 2008 PMID： 18436348 DOI： 10.1016/j.ejmech.2008.03.003
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514