| Literature DB >> 17085048 |
Tao Liu1, Zhongmiao Xu, Qiaojun He, Yanhong Chen, Bo Yang, Yongzhou Hu.
Abstract
A novel series of nitrogen-containing flavonoids 5a-l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors. The representative compounds 5a, 5b, 5e, and 5g showed potent CDK1/Cyclin B inhibitory activities. All compounds displayed a significant growth inhibitory action in vitro against Bel-7402, PC-3, ECA-109, A-549, HL-60, and MCF-7 cancer cell lines. Flow cytometry analysis showed that 5b induced apoptosis in PC-3 cells.Entities:
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Year: 2006 PMID： 17085048 DOI： 10.1016/j.bmcl.2006.07.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823