Literature DB >> 3619920

Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro.

P Lestienne.   

Abstract

Indirect experiments suggest that DNA polymerase gamma is involved in the mitochondrial DNA replication process. This report describes an in vitro mitochondrial DNA replication assay directed by the origin of replication of the Heavy strand mt DNA. The assay requires all four dNTP, rNTP and an ATP regenerating system. Nuclease digestion experiments show that specific events occur at the mt origin of replication. Antibodies raised against the purified DNA polymerase gamma inhibit the DNA replication reaction.

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Year:  1987        PMID： 3619920     DOI： 10.1016/0006-291x(87)90767-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

Review 1.  Mitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosis.

Authors:  Linsheng Zhang; Sherine S L Chan; Daynna J Wolff
Journal:  Arch Pathol Lab Med       Date:  2011-07       Impact factor: 5.534

Review 2.  Structure and function relationships in mammalian DNA polymerases.

Authors:  Nicole M Hoitsma; Amy M Whitaker; Matthew A Schaich; Mallory R Smith; Max S Fairlamb; Bret D Freudenthal
Journal:  Cell Mol Life Sci       Date:  2019-11-13       Impact factor: 9.261

3.  Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Authors:  Olivier Boucherat; Thibaut Peterlini; Alice Bourgeois; Valérie Nadeau; Sandra Breuils-Bonnet; Stéphanie Boilet-Molez; François Potus; Jolyane Meloche; Sophie Chabot; Caroline Lambert; Eve Tremblay; Young Chan Chae; Dario C Altieri; Gopinath Sutendra; Evangelos D Michelakis; Roxane Paulin; Steeve Provencher; Sébastien Bonnet
Journal:  Am J Respir Crit Care Med       Date:  2018-07-01       Impact factor: 21.405

4.  Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function.

Authors:  Ming Zhuo; Murat F Gorgun; Ella W Englander
Journal:  Free Radic Biol Med       Date:  2018-04-23       Impact factor: 7.376

Review 5.  DNA polymerases in the mitochondria: A critical review of the evidence.

Authors:  Rachel Krasich; William C Copeland
Journal:  Front Biosci (Landmark Ed)       Date:  2017-01-01

6.  Whole Exome Sequencing Is the Preferred Strategy to Identify the Genetic Defect in Patients With a Probable or Possible Mitochondrial Cause.

Authors:  Tom E J Theunissen; Minh Nguyen; Rick Kamps; Alexandra T Hendrickx; Suzanne C E H Sallevelt; Ralph W H Gottschalk; Chantal M Calis; Alphons P M Stassen; Bart de Koning; Elvira N M Mulder-Den Hartog; Kees Schoonderwoerd; Sabine A Fuchs; Yvonne Hilhorst-Hofstee; Marianne de Visser; Jo Vanoevelen; Radek Szklarczyk; Mike Gerards; Irenaeus F M de Coo; Debby M E I Hellebrekers; Hubert J M Smeets
Journal:  Front Genet       Date:  2018-10-12       Impact factor: 4.599

7.  Molecular Characterization of Portuguese Patients with Hereditary Cerebellar Ataxia.

Authors:  Mariana Santos; Joana Damásio; Susana Carmona; João Luís Neto; Nadia Dehghani; Leonor Correia Guedes; Clara Barbot; José Barros; José Brás; Jorge Sequeiros; Rita Guerreiro
Journal:  Cells       Date:  2022-03-12       Impact factor: 6.600
  7 in total

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